| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/19/2010 | at | LSU |
| L 5-4 |
|
| 2/20/2010 | at | LSU |
| L 25-8 | 1,000th career win for LSU's Paul Mainieri |
| 2/21/2010 | at | LSU |
| L 4-0 |
|
| 2/26/2010 |
| Grambling State |
|
| PPD to 2/28, rain |
| 2/26/2010 |
| Grambling State |
|
| PPD to 2/28, rain |
| 2/27/2010 |
| Grambling State |
| W 10-0 |
|
| 2/27/2010 |
| Grambling State |
| W 7-2 | 7 innings |
| 2/28/2010 |
| Grambling State |
| W 10-2 | makeup of 2/26 game |
| 2/28/2010 |
| Grambling State |
| W 6-5 | 8 innings (makeup of 2/26 game) |
| 3/3/2010 | at | Northwestern State |
| L 11-2 |
|
| 3/5/2010 |
| Gonzaga |
| W 2-1 | 10 innings |
| 3/6/2010 |
| Gonzaga |
| L 12-5 |
|
| 3/7/2010 |
| Gonzaga |
| L 9-2 |
|
| 3/11/2010 |
| Texas College |
| W 11-3 | 7 innings, rain |
| 3/16/2010 | at | Texas A&M |
|
| PPD to 5/12, impending weather |
| 3/19/2010 | vs | Georgia State |
| L 10-9 | Governors Challenge, Clarksville, TN |
| 3/20/2010 | vs | Georgia State |
| W 17-13 | Governors Challenge, Clarksville, TN |
| 3/20/2010 | at | Austin Peay State |
| L 7-0 | Governors Challenge, Clarksville, TN |
| 3/21/2010 | at | Austin Peay State |
|
| CCD, rain (Governors Challenge, Clarksville, TN) |
| 3/27/2010 |
| Binghamton |
| L 16-0 |
|
| 3/27/2010 |
| Binghamton |
| L 7-6 | 7 innings |
| 3/28/2010 |
| Binghamton |
| W 5-3 |
|
| 3/30/2010 | at | Arkansas |
| L 18-2 |
|
| 3/31/2010 | at | Arkansas |
| L 9-4 |
|
| 4/2/2010 |
| UT Pan American |
| W 6-4 |
|
| 4/3/2010 |
| UT Pan American |
| W 9-3 |
|
| 4/4/2010 |
| UT Pan American |
| L 4-2 |
|
| 4/9/2010 | at | Southern Utah | * | L 4-3 | 11 innings |
| 4/9/2010 | at | Southern Utah | * | W 9-8 |
|
| 4/10/2010 | at | Southern Utah | * | W 7-5 |
|
| 4/10/2010 | at | Southern Utah | * | W 3-2 | 8 innings |
| 4/16/2010 |
| North Dakota State | * | W 7-5 |
|
| 4/17/2010 |
| North Dakota State | * | W 4-2 |
|
| 4/17/2010 |
| North Dakota State | * | W 5-0 | 7 innings |
| 4/18/2010 |
| North Dakota State | * | W 8-2 |
|
| 4/20/2010 |
| Hawaii |
| L 5-2 |
|
| 4/23/2010 | at | Oakland | * | W 4-1 |
|
| 4/24/2010 | at | Oakland | * | W 8-5 | 14 innings |
| 4/24/2010 | at | Oakland | * | L 10-5 | 7 innings |
| 4/25/2010 | at | Oakland | * |
| CCD, field conditions |
| 4/27/2010 |
| Northwestern State |
| W 2-1 | 10 innings |
| 4/30/2010 | at | South Dakota State | * | W 19-7 | 7 innings |
| 5/1/2010 | at | South Dakota State | * | L 7-4 |
|
| 5/1/2010 | at | South Dakota State | * | W 8-3 | 7 innings |
| 5/2/2010 | at | South Dakota State | * | L 9-7 |
|
| 5/7/2010 |
| Western Illinois | * |
| PPD |
| 5/8/2010 |
| Western Illinois | * |
| PPD |
| 5/8/2010 |
| Western Illinois | * |
| PPD |
| 5/9/2010 |
| Western Illinois | * |
| CCD |
| 5/12/2010 | at | Texas A&M |
| L 15-3 | makeup of 3/16 game |
| 5/14/2010 |
| Oral Roberts | * | W 11-1 | 7 innings, run rule |
| 5/15/2010 |
| Oral Roberts | * | W 17-7 | 7 innings, run rule |
| 5/15/2010 |
| Oral Roberts | * |
| Suspended to 5/16, field conditions (4-1 ORU, t5) |
| 5/16/2010 |
| Oral Roberts | * | L 13-5 | 7 innings (Resumption of 5/15 game) |
| 5/16/2010 |
| Oral Roberts | * | L 19-1 | 7 innings |
| 5/17/2010 |
| Western Illinois | * | L 18-7 | 7 innings, run rule (makeup of 5/7 game) |
| 5/18/2010 |
| Western Illinois | * | W 13-7 | makeup of 5/8 game |
| 5/18/2010 |
| Western Illinois | * | W 7-6 | 8 innings (makeup of 5/8 game) |
| 5/21/2010 | at | IUPU-Fort Wayne | * | W 11-6 |
|
| 5/21/2010 | at | IUPU-Fort Wayne | * | L 4-1 | 5 innings, rain |
| 5/22/2010 | at | IUPU-Fort Wayne | * | L 4-3 |
|
| 5/22/2010 | at | IUPU-Fort Wayne | * | W 6-2 | 7 innings |
| 5/27/2010 | vs | Oral Roberts | SUMMIT-02 | L 4-2 | Summit Tournament, Game 2 (Tulsa, OK) |
| 5/28/2010 | vs | Oakland | SUMMIT-03 | L 7-2 | Summit Tournament, Game 3 (Tulsa, OK) |
| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/26/2010 | at | Mississippi |
| L 9-1 |
|
| 2/27/2010 | at | Mississippi |
| L 10-2 |
|
| 2/28/2010 | at | Mississippi |
| L 9-3 |
|
| 3/5/2010 | at | Memphis |
| W 6-4 |
|
| 3/6/2010 | at | Memphis |
| L 7-1 |
|
| 3/7/2010 | at | Memphis |
| L 16-6 |
|
| 3/12/2010 | at | Wright State |
| L 12-5 | Dayton Classic, Dayton, OH |
| 3/13/2010 | at | Dayton |
|
| PPD to 3/14, rain (Dayton Classic, Dayton, OH) |
| 3/13/2010 | at | Dayton |
|
| PPD to 3/14, rain (Dayton Classic, Dayton, OH) |
| 3/14/2010 | at | Dayton |
| W 6-5 | makeup of 3/13 game (Dayton Classic, Dayton, OH) |
| 3/14/2010 | at | Dayton |
|
| CCD, field conditions (makeup of 3/13 game (Dayton Classic, Dayton, OH)) |
| 3/14/2010 | vs | Indiana State |
|
| CCD, scheduling conflict (Dayton Classic, Dayton, OH) |
| 3/19/2010 | at | Xavier |
| L 6-5 |
|
| 3/20/2010 | at | Xavier |
| W 2-1 | 10 innings |
| 3/20/2010 | at | Xavier |
| L 3-2 | moved from 3/21, impending weather |
| 3/24/2010 | at | Toledo |
| L 20-4 |
|
| 3/26/2010 | at | Michigan State |
| L 8-0 |
|
| 3/27/2010 | at | Michigan State |
| L 4-2 |
|
| 3/27/2010 | at | Michigan State |
| L 11-2 |
|
| 3/28/2010 | at | Michigan State |
| L 10-3 |
|
| 3/30/2010 | at | Western Michigan |
| L 5-4 |
|
| 4/2/2010 |
| Concordia (MI) |
| W 9-7 | 7 innings |
| 4/2/2010 |
| Concordia (MI) |
| W 12-4 | 7 innings |
| 4/6/2010 | at | Notre Dame |
| L 13-6 |
|
| 4/9/2010 | at | Oral Roberts | * | L 10-0 |
|
| 4/10/2010 | at | Oral Roberts | * | L 12-6 |
|
| 4/10/2010 | at | Oral Roberts | * | L 5-2 | 7 innings |
| 4/11/2010 | at | Oral Roberts | * | L 4-2 |
|
| 4/14/2010 |
| Eastern Michigan |
| L 11-1 |
|
| 4/16/2010 |
| South Dakota State | * | L 13-2 | 8 innings |
| 4/17/2010 |
| South Dakota State | * | L 13-3 | 7 innings |
| 4/17/2010 |
| South Dakota State | * | W 3-1 | 7 innings |
| 4/18/2010 |
| South Dakota State | * | W 7-5 |
|
| 4/20/2010 |
| Toledo |
| W 5-3 |
|
| 4/23/2010 |
| Centenary | * | L 4-1 |
|
| 4/24/2010 |
| Centenary | * | L 8-5 | 14 innings |
| 4/24/2010 |
| Centenary | * | W 10-5 | 7 innings |
| 4/25/2010 |
| Centenary | * |
| CCD, field conditions |
| 4/28/2010 |
| Central Michigan |
| W 10-9 |
|
| 4/30/2010 | at | Western Illinois | * | W 4-1 | 6 innings, inclement weather |
| 5/1/2010 | at | Western Illinois | * | W 7-4 |
|
| 5/1/2010 | at | Western Illinois | * | W 10-7 | 7 innings |
| 5/2/2010 | at | Western Illinois | * | W 11-6 |
|
| 5/4/2010 |
| Olivet |
| W 19-10 | 7 innings |
| 5/4/2010 |
| Olivet |
| W 5-4 | 8 innings |
| 5/5/2010 |
| Western Michigan |
| L 9-8 |
|
| 5/7/2010 | at | North Dakota State | * |
| PPD to 5/9, rain |
| 5/8/2010 | at | North Dakota State | * | L 7-3 |
|
| 5/8/2010 | at | North Dakota State | * | L 5-4 |
|
| 5/9/2010 | at | North Dakota State | * | W 8-7 |
|
| 5/9/2010 | at | North Dakota State | * | L 5-1 | 7 innings (makeup of 5/7 game) |
| 5/11/2010 | at | Central Michigan |
|
| CCD, rain |
| 5/12/2010 | at | Eastern Michigan |
| L 17-1 |
|
| 5/14/2010 |
| IUPU-Fort Wayne | * | L 14-3 |
|
| 5/15/2010 |
| IUPU-Fort Wayne | * | L 6-2 |
|
| 5/15/2010 |
| IUPU-Fort Wayne | * | L 7-3 | 7 innings |
| 5/16/2010 |
| IUPU-Fort Wayne | * | W 7-1 |
|
| 5/20/2010 |
| Southern Utah | * | W 13-12 |
|
| 5/21/2010 |
| Southern Utah | * | W 10-7 |
|
| 5/21/2010 |
| Southern Utah | * | W 4-0 | No-hitter for Aaron Wick (first for OU at D1-level) (7 innings) |
| 5/22/2010 |
| Southern Utah | * | W 11-4 |
|
| 5/27/2010 | vs | South Dakota State | SUMMIT-01 | L 6-5 | Summit Tournament, Game 1 (Tulsa, OK) (10 innings) |
| 5/28/2010 | vs | Centenary | SUMMIT-03 | W 7-2 | Summit Tournament, Game 3 (Tulsa, OK) |
| 5/28/2010 | vs | South Dakota State | SUMMIT-05 | L 20-6 | Summit Tournament, Game 5 (Tulsa, OK) |