| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/19/2010 |
| Prairie View A&M |
|
| CCD, inclement weather |
| 2/20/2010 |
| Prairie View A&M |
|
| PPD to 2/21, field conditions |
| 2/21/2010 |
| Prairie View A&M |
| W 9-6 |
|
| 2/21/2010 |
| Prairie View A&M |
| W 8-5 | makeup of 2/20 game |
| 2/23/2010 |
| Houston Baptist |
|
| PPD, rain |
| 2/25/2010 | at | Houston-Victoria |
| W 13-6 |
|
| 2/26/2010 | vs | Nebraska |
| L 21-9 | Rice Invitational, Houston, TX |
| 2/27/2010 | vs | Elon |
| W 16-12 | Rice Invitational, Houston, TX |
| 2/28/2010 | at | Rice |
| L 7-2 | Rice Invitational, Houston, TX |
| 3/2/2010 |
| Texas A&M-Kingsville |
| W 11-6 |
|
| 3/5/2010 | at | Texas State | * | L 5-3 |
|
| 3/6/2010 | at | Texas State | * | W 10-8 |
|
| 3/7/2010 | at | Texas State | * | L 13-8 |
|
| 3/9/2010 |
| UT Brownsville |
| W 14-5 |
|
| 3/12/2010 |
| UCLA |
| L 11-3 | Whataburger College Classic, Corpus Christi, TX |
| 3/13/2010 |
| Oklahoma |
| L 11-2 | Whataburger College Classic, Corpus Christi, TX |
| 3/14/2010 |
| Mississippi State |
| | Whataburger College Classic, Corpus Christi, TX |
| 3/14/2010 |
| Mississippi State |
| | Whataburger College Classic, Corpus Christi, TX |
| 3/17/2010 |
| Houston Baptist |
|
| makeup of 2/23 game |
| 3/19/2010 |
| Nicholls State | * |
|
|
| 3/20/2010 |
| Nicholls State | * |
|
|
| 3/21/2010 |
| Nicholls State | * |
|
|
| 3/23/2010 | at | Texas Tech |
|
|
|
| 3/24/2010 | at | Texas Tech |
|
|
|
| 3/26/2010 | at | McNeese State | * |
|
|
| 3/27/2010 | at | McNeese State | * |
|
|
| 3/28/2010 | at | McNeese State | * |
|
|
| 3/30/2010 |
| UT Pan American |
|
|
|
| 4/1/2010 |
| UTSA | * |
|
|
| 4/2/2010 |
| UTSA | * |
|
|
| 4/3/2010 |
| UTSA | * |
|
|
| 4/6/2010 | at | Texas |
|
|
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| 4/7/2010 | at | Texas |
|
|
|
| 4/9/2010 |
| Lamar | * |
|
|
| 4/10/2010 |
| Lamar | * |
|
|
| 4/11/2010 |
| Lamar | * |
|
|
| 4/14/2010 | at | Rice |
|
|
|
| 4/16/2010 | at | Stephen F. Austin | * |
|
|
| 4/17/2010 | at | Stephen F. Austin | * |
|
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| 4/18/2010 | at | Stephen F. Austin | * |
|
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| 4/20/2010 | at | UT Pan American |
|
|
|
| 4/23/2010 |
| Southeastern Louisiana | * |
|
|
| 4/24/2010 |
| Southeastern Louisiana | * |
|
|
| 4/25/2010 |
| Southeastern Louisiana | * |
|
|
| 4/27/2010 |
| UT Pan American |
|
|
|
| 4/28/2010 | at | Texas Southern |
|
|
|
| 4/30/2010 |
| UT Arlington | * |
|
|
| 5/1/2010 |
| UT Arlington | * |
|
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| 5/2/2010 |
| UT Arlington | * |
|
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| 5/7/2010 | at | Central Arkansas | * |
|
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| 5/8/2010 | at | Central Arkansas | * |
|
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| 5/9/2010 | at | Central Arkansas | * |
|
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| 5/14/2010 | at | Northwestern State | * |
|
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| 5/15/2010 | at | Northwestern State | * |
|
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| 5/16/2010 | at | Northwestern State | * |
|
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| 5/20/2010 |
| Sam Houston State | * |
|
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| 5/21/2010 |
| Sam Houston State | * |
|
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| 5/22/2010 |
| Sam Houston State | * |
|
|