| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/19/2010 |
| Xavier |
| W 16-6 |
|
| 2/20/2010 |
| Xavier |
| W 7-6 |
|
| 2/21/2010 |
| Xavier |
| W 17-1 |
|
| 2/26/2010 | at | Oregon State |
| L 17-1 | Pape Grand Slam, Corvallis, OR |
| 2/27/2010 | at | Oregon State |
| W 9-2 | Pape Grand Slam, Corvallis, OR |
| 2/28/2010 | at | Oregon State |
| L 1-0 | Pape Grand Slam, Corvallis, OR |
| 3/3/2010 |
| Eastern Kentucky |
| L 8-7 | 10 innings |
| 3/5/2010 |
| Binghamton |
| L 7-4 | Tennessee Tournament, Knoxville, TN |
| 3/6/2010 |
| Kennesaw State |
| L 4-2 | Tennessee Tournament, Knoxville, TN |
| 3/6/2010 |
| Binghamton |
| W 19-2 | Tennessee Tournament, Knoxville, TN |
| 3/7/2010 |
| Kennesaw State |
| W 3-2 | 11 innings (Tennessee Tournament, Knoxville, TN) |
| 3/9/2010 | at | Western Kentucky |
| L 5-4 | 10 innings |
| 3/10/2010 | at | Middle Tennessee State |
| W 8-6 |
|
| 3/12/2010 |
| Connecticut |
|
| PPD to 3/13, rain (Arby's Classic, Knoxville, TN) |
| 3/13/2010 |
| Connecticut |
| W 3-2 | makeup of 3/12 game (Arby's Classic, Knoxville, TN) |
| 3/14/2010 |
| Ohio State |
| L 2-0 | Arby's Classic, Knoxville, TN |
| 3/14/2010 |
| Marshall |
| W 13-8 | Arby's Classic, Knoxville, TN |
| 3/17/2010 |
| Morehead State |
| W 13-2 |
|
| 3/19/2010 | at | South Carolina | * | |
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| 3/20/2010 | at | South Carolina | * | |
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| 3/21/2010 | at | South Carolina | * | |
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| 3/23/2010 |
| South Carolina-Upstate |
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| 3/26/2010 |
| LSU | * |
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| 3/27/2010 |
| LSU | * |
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| 3/28/2010 |
| LSU | * |
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| 3/30/2010 |
| Tennessee Tech |
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| 3/31/2010 |
| Presbyterian |
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| 4/2/2010 | at | Mississippi | * |
|
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| 4/3/2010 | at | Mississippi | * |
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| 4/4/2010 | at | Mississippi | * |
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| 4/7/2010 |
| Western Carolina |
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| 4/9/2010 |
| Florida | * |
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| 4/10/2010 |
| Florida | * |
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| 4/11/2010 |
| Florida | * |
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| 4/13/2010 |
| Lipscomb |
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| 4/16/2010 | at | Mississippi State | * |
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| 4/17/2010 | at | Mississippi State | * |
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| 4/18/2010 | at | Mississippi State | * |
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| 4/21/2010 | at | Western Carolina |
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| 4/23/2010 |
| Vanderbilt | * |
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| 4/24/2010 |
| Vanderbilt | * |
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| 4/25/2010 |
| Vanderbilt | * |
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| 4/27/2010 |
| Belmont |
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| 4/30/2010 |
| Kentucky | * |
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| 5/1/2010 |
| Kentucky | * |
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| 5/2/2010 |
| Kentucky | * |
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| 5/7/2010 | at | Georgia | * |
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| 5/8/2010 | at | Georgia | * |
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| 5/9/2010 | at | Georgia | * |
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| 5/12/2010 |
| Middle Tennessee State |
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| 5/14/2010 | at | Auburn | * |
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| 5/15/2010 | at | Auburn | * |
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| 5/16/2010 | at | Auburn | * |
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| 5/18/2010 |
| UNC Asheville |
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| 5/20/2010 |
| Alabama | * |
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| 5/21/2010 |
| Alabama | * |
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| 5/22/2010 |
| Alabama | * |
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