| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/19/2010 | at | Samford |
| L 9-4 |
|
| 2/20/2010 | at | Samford |
| L 9-5 |
|
| 2/20/2010 | at | Samford |
| W 5-4 | 7 innings |
| 2/21/2010 | at | Samford |
| W 10-6 |
|
| 2/26/2010 | vs | Radford |
| W 3-2 | Charleston Crab House Shootout, Charleston, SC |
| 2/27/2010 | at | The Citadel |
| L 4-1 | Charleston Crab House Shootout, Charleston, SC |
| 2/28/2010 | vs | St. Joseph's |
| W 10-2 | Charleston Crab House Shootout, Charleston, SC |
| 3/5/2010 | at | Georgia Southern |
| L 9-1 |
|
| 3/6/2010 | at | Georgia Southern |
| L 4-3 |
|
| 3/7/2010 | at | Georgia Southern |
| W 8-0 |
|
| 3/12/2010 | vs | Ohio State |
|
| PPD to 3/13, rain (Arby's Classic, Knoxville, TN) |
| 3/13/2010 | vs | Ohio State |
| W 17-1 | makeup of 3/12 game (Arby's Classic, Knoxville, TN) |
| 3/13/2010 | vs | Connecticut |
| W 11-8 | Arby's Classic, Knoxville, TN |
| 3/14/2010 | at | Tennessee |
| L 13-8 | Arby's Classic, Knoxville, TN |
| 3/19/2010 |
| LeMoyne |
| L 5-4 |
|
| 3/20/2010 |
| LeMoyne |
| L 12-3 |
|
| 3/20/2010 |
| LeMoyne |
| L 7-2 | 7 innings |
| 3/21/2010 |
| LeMoyne |
| W 11-7 |
|
| 3/23/2010 | at | Virginia |
| L 6-3 |
|
| 3/24/2010 |
| Ohio |
| W 10-4 |
|
| 3/26/2010 | at | Tulane | * | L 4-3 |
|
| 3/27/2010 | at | Tulane | * | W 7-3 |
|
| 3/28/2010 | at | Tulane | * | L 6-2 |
|
| 3/31/2010 | at | Eastern Kentucky |
| L 10-6 |
|
| 4/2/2010 |
| Memphis | * | W 7-4 |
|
| 4/3/2010 |
| Memphis | * | L 10-8 |
|
| 4/3/2010 |
| Memphis | * | L 21-13 |
|
| 4/7/2010 | at | Ohio |
| L 15-5 |
|
| 4/9/2010 | at | UAB | * | W 7-3 |
|
| 4/10/2010 | at | UAB | * | L 12-4 |
|
| 4/11/2010 | at | UAB | * | W 14-4 | 7 innings, run rule |
| 4/13/2010 | at | Morehead State |
| L 15-6 |
|
| 4/14/2010 |
| Eastern Kentucky |
| L 10-0 |
|
| 4/16/2010 |
| Southern Mississippi | * | L 16-7 |
|
| 4/17/2010 |
| Southern Mississippi | * | W 6-3 |
|
| 4/18/2010 |
| Southern Mississippi | * | W 6-3 |
|
| 4/21/2010 | vs | Coppin State |
| W 10-4 | 7 innings (Beckley, WV) |
| 4/21/2010 | vs | Coppin State |
| W 7-3 | 7 innings (Beckley, WV) |
| 4/23/2010 |
| UCF | * | W 7-2 |
|
| 4/24/2010 |
| UCF | * | W 6-5 |
|
| 4/25/2010 |
| UCF | * | W 5-3 |
|
| 4/27/2010 |
| Morehead State |
| L 3-2 |
|
| 4/28/2010 | at | Ohio State |
| L 7-4 |
|
| 4/30/2010 | at | East Carolina | * | L 11-4 |
|
| 5/1/2010 | at | East Carolina | * | L 12-3 |
|
| 5/2/2010 | at | East Carolina | * | W 10-3 |
|
| 5/7/2010 |
| Rice | * | L 20-4 |
|
| 5/8/2010 |
| Rice | * | W 4-3 |
|
| 5/9/2010 |
| Rice | * | L 14-4 |
|
| 5/12/2010 |
| Morehead State |
|
| PPD, inclement weather |
| 5/14/2010 | at | Houston | * |
| PPD to 5/15, inclement weather |
| 5/15/2010 | at | Houston | * | L 11-6 |
|
| 5/15/2010 | at | Houston | * | W 5-3 | makeup of 5/14 game |
| 5/16/2010 | at | Houston | * | L 10-1 |
|
| 5/18/2010 | vs | Radford |
| L 15-5 | Beckley, WV |
| 5/20/2010 |
| Wright State |
| W 9-7 |
|
| 5/21/2010 |
| Wright State |
| W 4-3 |
|
| 5/21/2010 |
| Wright State |
| W 3-2 | 7 innings (moved from 5/22, impending weather) |
| 5/26/2010 | vs | Houston | CUSA-03 | L 11-7 | Conference USA Tournament, Game 3 (Houston, TX) |
| 5/27/2010 | vs | Memphis | CUSA-05 | W 10-7 | Conference USA Tournament, Game 5 (Houston, TX) |
| 5/28/2010 | vs | Rice | CUSA-08 | L 18-0 | Conference USA Tournament, Game 8 (Houston, TX) (7 innings, run rule) |
| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/19/2010 | at | Stanford |
| L 6-4 |
|
| 2/20/2010 | at | Stanford |
| L 14-5 |
|
| 2/20/2010 | at | Stanford |
| L 7-6 | moved from 2/21, impending weather |
| 2/23/2010 |
| Texas State |
|
| PPD, rain |
| 2/24/2010 |
| Lamar |
| L 13-7 |
|
| 2/26/2010 |
| Elon |
| W 7-2 | Rice Invitational, Houston, TX |
| 2/27/2010 |
| Nebraska |
| W 4-3 | Rice Invitational, Houston, TX |
| 2/28/2010 |
| Texas A&M-Corpus Christi |
| W 7-2 | Rice Invitational, Houston, TX |
| 3/2/2010 |
| Houston |
| W 8-2 |
|
| 3/3/2010 | at | Texas State |
| W 5-0 |
|
| 3/5/2010 | vs | Texas |
| L 2-1 | Houston College Classic, Houston, TX |
| 3/6/2010 | vs | Texas Tech |
| W 3-2 | Houston College Classic, Houston, TX |
| 3/7/2010 | vs | TCU |
| W 5-4 | Houston College Classic, Houston, TX |
| 3/9/2010 |
| Sam Houston State |
| W 8-1 |
|
| 3/11/2010 |
| California |
| L 8-6 |
|
| 3/12/2010 |
| California |
| L 6-4 |
|
| 3/13/2010 |
| California |
| W 26-11 |
|
| 3/14/2010 |
| California |
| W 7-4 |
|
| 3/16/2010 |
| Texas |
| W 10-6 |
|
| 3/19/2010 | at | San Diego |
| L 6-4 |
|
| 3/20/2010 | at | San Diego |
| L 6-5 | 10 innings |
| 3/21/2010 | at | San Diego |
| W 9-8 |
|
| 3/23/2010 | at | Texas |
| L 5-1 |
|
| 3/26/2010 | at | Memphis | * | L 5-2 |
|
| 3/27/2010 | at | Memphis | * | L 8-7 |
|
| 3/27/2010 | at | Memphis | * | W 13-4 | moved from 3/28, impending weather |
| 3/30/2010 | at | Lamar |
| W 7-2 |
|
| 4/1/2010 |
| Houston | * | W 6-0 |
|
| 4/2/2010 |
| Houston | * | W 11-2 |
|
| 4/3/2010 |
| Houston | * | W 8-7 | 12 innings |
| 4/6/2010 |
| Dallas Baptist |
| L 7-6 |
|
| 4/9/2010 | at | Tulane | * | L 6-5 |
|
| 4/10/2010 | at | Tulane | * | W 11-8 |
|
| 4/11/2010 | at | Tulane | * | W 19-1 | 7 innings, run rule |
| 4/13/2010 | at | Sam Houston State |
| W 8-7 |
|
| 4/14/2010 |
| Texas A&M-Corpus Christi |
| W 23-1 | 7 innings |
| 4/16/2010 | at | UCF | * | W 9-2 |
|
| 4/17/2010 | at | UCF | * | L 6-4 |
|
| 4/18/2010 | at | UCF | * | W 13-8 |
|
| 4/20/2010 | at | Texas A&M |
| L 7-1 |
|
| 4/23/2010 |
| East Carolina | * | W 20-3 |
|
| 4/24/2010 |
| East Carolina | * | W 3-2 |
|
| 4/25/2010 |
| East Carolina | * | W 11-9 |
|
| 5/4/2010 |
| Texas State |
| W 16-2 | makeup of 2/23 game |
| 5/5/2010 |
| Texas Southern |
| W 16-9 |
|
| 5/7/2010 | at | Marshall | * | W 20-4 |
|
| 5/8/2010 | at | Marshall | * | L 4-3 |
|
| 5/9/2010 | at | Marshall | * | W 14-4 |
|
| 5/11/2010 | at | Oklahoma State |
| L 12-5 |
|
| 5/14/2010 |
| Southern Mississippi | * |
| PPD to 5/15, inclement weather |
| 5/15/2010 |
| Southern Mississippi | * | L 11-10 |
|
| 5/15/2010 |
| Southern Mississippi | * | W 10-2 | makeup of 5/14 game |
| 5/16/2010 |
| Southern Mississippi | * | W 21-14 |
|
| 5/18/2010 | at | Houston |
| W 15-5 |
|
| 5/20/2010 |
| UAB | * | W 5-2 |
|
| 5/21/2010 |
| UAB | * | W 9-2 |
|
| 5/22/2010 |
| UAB | * | L 8-5 |
|
| 5/26/2010 | vs | East Carolina | CUSA-02 | W 11-3 | Conference USA Tournament, Game 2 (Houston, TX) |
| 5/27/2010 | vs | Houston | CUSA-06 | W 24-3 | Conference USA Tournament, Game 6 (Houston, TX) (7 innings, run rule) |
| 5/28/2010 | vs | Marshall | CUSA-08 | W 18-0 | Conference USA Tournament, Game 8 (Houston, TX) (7 innings, run rule) |
| 5/29/2010 | vs | Southern Mississippi | CUSA-10 | L 7-4 | Conference USA Tournament, Game 10 (Houston, TX) |
| 6/4/2010 | vs | Louisiana-Lafayette |
| L 1-0 | Austin Regional, Game 2 |
| 6/5/2010 | vs | Rider |
| W 19-1 | Austin Regional, Game 3 |
| 6/6/2010 | vs | Louisiana-Lafayette |
| W 9-1 | Austin Regional, Game 5 |
| 6/6/2010 | vs | Texas |
| L 4-1 | Austin Regional, Game 6 |