| Game Date |
| Opponent | Conference Game | Result | Commentary |
|---|
| 2/19/2010 | at | Samford |
| L 9-4 |
|
| 2/20/2010 | at | Samford |
| L 9-5 |
|
| 2/20/2010 | at | Samford |
| W 5-4 | 7 innings |
| 2/21/2010 | at | Samford |
| W 10-6 |
|
| 2/26/2010 | vs | Radford |
| W 3-2 | Charleston Crab House Shootout, Charleston, SC |
| 2/27/2010 | at | The Citadel |
| L 4-1 | Charleston Crab House Shootout, Charleston, SC |
| 2/28/2010 | vs | St. Joseph's |
| W 10-2 | Charleston Crab House Shootout, Charleston, SC |
| 3/5/2010 | at | Georgia Southern |
| L 9-1 |
|
| 3/6/2010 | at | Georgia Southern |
| L 4-3 |
|
| 3/7/2010 | at | Georgia Southern |
| W 8-0 |
|
| 3/12/2010 | vs | Ohio State |
|
| PPD to 3/13, rain (Arby's Classic, Knoxville, TN) |
| 3/13/2010 | vs | Ohio State |
| W 17-1 | makeup of 3/12 game (Arby's Classic, Knoxville, TN) |
| 3/13/2010 | vs | Connecticut |
| W 11-8 | Arby's Classic, Knoxville, TN |
| 3/14/2010 | at | Tennessee |
| L 13-8 | Arby's Classic, Knoxville, TN |
| 3/19/2010 |
| LeMoyne |
| |
|
| 3/20/2010 |
| LeMoyne |
| |
|
| 3/20/2010 |
| LeMoyne |
| |
|
| 3/21/2010 |
| LeMoyne |
|
|
|
| 3/23/2010 | at | Virginia |
|
|
|
| 3/24/2010 |
| Ohio |
|
|
|
| 3/26/2010 | at | Tulane | * |
|
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| 3/27/2010 | at | Tulane | * |
|
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| 3/28/2010 | at | Tulane | * |
|
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| 3/31/2010 | at | Eastern Kentucky |
|
|
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| 4/2/2010 |
| Memphis | * |
|
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| 4/3/2010 |
| Memphis | * |
|
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| 4/3/2010 |
| Memphis | * |
|
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| 4/7/2010 | at | Ohio |
|
|
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| 4/9/2010 | at | UAB | * |
|
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| 4/10/2010 | at | UAB | * |
|
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| 4/11/2010 | at | UAB | * |
|
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| 4/13/2010 | at | Morehead State |
|
|
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| 4/14/2010 |
| Eastern Kentucky |
|
|
|
| 4/16/2010 |
| Southern Mississippi | * |
|
|
| 4/17/2010 |
| Southern Mississippi | * |
|
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| 4/18/2010 |
| Southern Mississippi | * |
|
|
| 4/23/2010 |
| UCF | * |
|
|
| 4/24/2010 |
| UCF | * |
|
|
| 4/25/2010 |
| UCF | * |
|
|
| 4/27/2010 |
| Morehead State |
|
|
|
| 4/28/2010 | at | Ohio State |
|
|
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| 4/30/2010 | at | East Carolina | * |
|
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| 5/1/2010 | at | East Carolina | * |
|
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| 5/2/2010 | at | East Carolina | * |
|
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| 5/7/2010 |
| Rice | * |
|
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| 5/8/2010 |
| Rice | * |
|
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| 5/9/2010 |
| Rice | * |
|
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| 5/12/2010 |
| Morehead State |
|
|
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| 5/14/2010 | at | Houston | * |
|
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| 5/15/2010 | at | Houston | * |
|
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| 5/16/2010 | at | Houston | * |
|
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| 5/18/2010 |
| Radford |
|
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| 5/20/2010 |
| Wright State |
|
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| 5/21/2010 |
| Wright State |
|
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| 5/22/2010 |
| Wright State |
|
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