| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/19/2010 |
| West Virginia |
| W 4-2 | Caravelle Resort Tournament, Conway, SC |
| 2/20/2010 |
| Virginia Tech |
| W 13-5 | Caravelle Resort Tournament, Conway, SC |
| 2/21/2010 |
| Kentucky |
| L 3-2 | Caravelle Resort Tournament, Conway, SC |
| 2/23/2010 | at | Wake Forest |
| W 2-0 |
|
| 2/25/2010 |
| UC Irvine |
|
| PPD to 2/27, cold (Baseball at the Beach, Myrtle Beach, SC) |
| 2/26/2010 |
| James Madison |
| W 11-7 | Baseball at the Beach, Myrtle Beach, SC |
| 2/27/2010 |
| UC Irvine |
| W 7-3 | Baseball at the Beach, Myrtle Beach, SC |
| 2/27/2010 |
| UC Irvine |
| W 13-6 | makeup of 2/25 game (Baseball at the Beach, Myrtle Beach, SC) |
| 2/28/2010 |
| NC State |
| W 6-3 | Baseball at the Beach, Myrtle Beach, SC |
| 3/5/2010 |
| Toledo |
| W 14-4 | Caravelle Resort Invitational, Conway, SC |
| 3/6/2010 |
| Pittsburgh |
| W 9-6 | Caravelle Resort Invitational, Conway, SC |
| 3/7/2010 |
| Ball State |
| W 3-2 | Caravelle Resort Invitational, Conway, SC |
| 3/8/2010 |
| Ball State |
| W 3-2 |
|
| 3/9/2010 |
| Wake Forest |
| W 9-4 |
|
| 3/12/2010 |
| Illinois |
| L 11-10 | Caravelle Resort Classic, Conway, SC |
| 3/13/2010 |
| Michigan |
| W 13-4 | Caravelle Resort Classic, Conway, SC |
| 3/13/2010 |
| Illinois |
| W 9-4 | Caravelle Resort Classic, Conway, SC |
| 3/14/2010 |
| Michigan |
| W 3-0 | Caravelle Resort Classic, Conway, SC |
| 3/16/2010 | at | College of Charleston |
| L 5-4 |
|
| 3/19/2010 | at | Charleston Southern | * | |
|
| 3/20/2010 | at | Charleston Southern | * | |
|
| 3/21/2010 | at | Charleston Southern | * | |
|
| 3/23/2010 | at | The Citadel |
|
|
|
| 3/26/2010 |
| San Diego |
|
|
|
| 3/27/2010 |
| San Diego |
|
|
|
| 3/28/2010 |
| San Diego |
|
|
|
| 3/31/2010 | at | Clemson |
|
|
|
| 4/2/2010 |
| Presbyterian | * |
|
|
| 4/3/2010 |
| Presbyterian | * |
|
|
| 4/3/2010 |
| Presbyterian | * |
|
|
| 4/6/2010 |
| UNC Wilmington |
|
|
|
| 4/9/2010 |
| High Point | * |
|
|
| 4/10/2010 |
| High Point | * |
|
|
| 4/11/2010 |
| High Point | * |
|
|
| 4/13/2010 |
| The Citadel |
|
|
|
| 4/14/2010 | at | North Carolina |
|
|
|
| 4/16/2010 | at | Gardner-Webb | * |
|
|
| 4/17/2010 | at | Gardner-Webb | * |
|
|
| 4/18/2010 | at | Gardner-Webb | * |
|
|
| 4/21/2010 | at | UNC Wilmington |
|
|
|
| 4/23/2010 | at | VMI | * |
|
|
| 4/24/2010 | at | VMI | * |
|
|
| 4/25/2010 | at | VMI | * |
|
|
| 4/27/2010 | at | Virginia |
|
|
|
| 4/30/2010 |
| UNC Asheville | * |
|
|
| 5/1/2010 |
| UNC Asheville | * |
|
|
| 5/2/2010 |
| UNC Asheville | * |
|
|
| 5/8/2010 |
| Winthrop | * |
|
|
| 5/9/2010 |
| Winthrop | * |
|
|
| 5/10/2010 |
| Winthrop | * |
|
|
| 5/14/2010 | at | Liberty | * |
|
|
| 5/15/2010 | at | Liberty | * |
|
|
| 5/16/2010 | at | Liberty | * |
|
|
| 5/18/2010 |
| College of Charleston |
|
|
|
| 5/20/2010 | at | Radford | * |
|
|
| 5/21/2010 | at | Radford | * |
|
|
| 5/22/2010 | at | Radford | * |
|
|
| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/19/2010 |
| Northwestern |
| W 8-4 | Bojangles Baseball Classic, Rock Hill, SC |
| 2/20/2010 |
| George Mason |
| W 11-4 | Bojangles Baseball Classic, Rock Hill, SC |
| 2/21/2010 |
| Marist |
| W 19-4 | Bojangles Baseball Classic, Rock Hill, SC |
| 2/22/2010 |
| Marist |
| W 10-9 | Bojangles Baseball Classic, Rock Hill, SC |
| 2/26/2010 |
| Wagner |
| W 3-2 |
|
| 2/27/2010 |
| Wagner |
| W 4-3 |
|
| 2/28/2010 |
| Wagner |
| W 16-4 |
|
| 3/2/2010 | at | Wake Forest |
|
| PPD to 3/3, inclement weather |
| 3/3/2010 | at | Wake Forest |
|
| PPD, field conditions (makeup of 3/2 game) |
| 3/5/2010 | at | Texas A&M |
| L 7-0 |
|
| 3/6/2010 | at | Texas A&M |
| L 12-4 |
|
| 3/7/2010 | at | Texas A&M |
| L 2-1 |
|
| 3/11/2010 |
| Toledo |
| L 5-4 | Johnny Gill Memorial Tournament, Rock Hill, SC |
| 3/12/2010 |
| Toledo |
| W 5-4 | Johnny Gill Memorial Tournament, Rock Hill, SC |
| 3/13/2010 |
| Canisius |
| W 3-2 | Johnny Gill Memorial Tournament, Rock Hill, SC |
| 3/14/2010 |
| Canisius |
| L 3-1 | Johnny Gill Memorial Tournament, Rock Hill, SC |
| 3/16/2010 |
| Harvard |
| W 12-5 |
|
| 3/18/2010 |
| Columbia |
| |
|
| 3/19/2010 |
| Columbia |
| | Coca-Cola Classic, Rock Hill, SC |
| 3/20/2010 |
| Kent State |
| | Coca-Cola Classic, Rock Hill, SC |
| 3/20/2010 |
| Penn State |
| | Coca-Cola Classic, Rock Hill, SC |
| 3/21/2010 |
| TBA |
| | Coca-Cola Classic, Rock Hill, SC |
| 3/24/2010 | at | The Citadel |
|
|
|
| 3/26/2010 |
| High Point | * |
|
|
| 3/27/2010 |
| High Point | * |
|
|
| 3/28/2010 |
| High Point | * |
|
|
| 3/30/2010 | at | North Carolina |
|
|
|
| 4/2/2010 | at | Gardner-Webb | * |
|
|
| 4/3/2010 | at | Gardner-Webb | * |
|
|
| 4/3/2010 | at | Gardner-Webb | * |
|
|
| 4/7/2010 |
| The Citadel |
|
|
|
| 4/9/2010 | at | Charleston Southern | * |
|
|
| 4/10/2010 | at | Charleston Southern | * |
|
|
| 4/11/2010 | at | Charleston Southern | * |
|
|
| 4/14/2010 | at | Charlotte |
|
|
|
| 4/16/2010 | at | UNC Asheville | * |
|
|
| 4/17/2010 | at | UNC Asheville | * |
|
|
| 4/18/2010 | at | UNC Asheville | * |
|
|
| 4/21/2010 | at | Georgia |
|
|
|
| 4/23/2010 |
| Radford | * |
|
|
| 4/24/2010 |
| Radford | * |
|
|
| 4/25/2010 |
| Radford | * |
|
|
| 4/27/2010 |
| Charlotte |
|
|
|
| 4/30/2010 |
| Presbyterian | * |
|
|
| 5/1/2010 |
| Presbyterian | * |
|
|
| 5/2/2010 |
| Presbyterian | * |
|
|
| 5/5/2010 | at | South Carolina |
|
|
|
| 5/8/2010 | at | Coastal Carolina | * |
|
|
| 5/9/2010 | at | Coastal Carolina | * |
|
|
| 5/10/2010 | at | Coastal Carolina | * |
|
|
| 5/11/2010 |
| Wake Forest |
|
|
|
| 5/14/2010 | at | VMI | * |
|
|
| 5/15/2010 | at | VMI | * |
|
|
| 5/16/2010 | at | VMI | * |
|
|
| 5/20/2010 |
| Liberty | * |
|
|
| 5/21/2010 |
| Liberty | * |
|
|
| 5/22/2010 |
| Liberty | * |
|
|