| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/19/2010 | at | Baylor |
| L 9-3 | QTI Apparel Opening Weekend Classic, Waco, TX |
| 2/20/2010 | at | Baylor |
| L 3-2 | QTI Apparel Opening Weekend Classic, Waco, TX |
| 2/20/2010 | vs | Georgia |
| W 9-5 | QTI Apparel Opening Weekend Classic, Waco, TX |
| 2/21/2010 | vs | Georgia |
| L 10-5 | QTI Apparel Opening Weekend Classic, Waco, TX |
| 2/26/2010 |
| Fordham |
| W 5-4 |
|
| 2/27/2010 |
| Fordham |
| W 11-4 |
|
| 2/28/2010 |
| Fordham |
| W 8-3 |
|
| 3/3/2010 |
| Xavier |
|
| CCD, field conditions (Cary, NC) |
| 3/5/2010 |
| Temple |
| W 3-0 |
|
| 3/6/2010 |
| Temple |
| W 7-0 |
|
| 3/7/2010 |
| Temple |
| W 8-2 |
|
| 3/8/2010 |
| Quinnipiac |
| W 10-3 | Cary, NC |
| 3/9/2010 |
| Quinnipiac |
| W 5-0 | Cary, NC |
| 3/10/2010 | at | Wofford |
|
| PPD to 5/21, impending weather |
| 3/12/2010 |
| North Carolina | * | L 21-9 |
|
| 3/13/2010 |
| North Carolina | * | W 15-11 |
|
| 3/14/2010 |
| North Carolina | * | W 5-3 |
|
| 3/17/2010 |
| Liberty |
| W 3-2 | 11 innings (Cary, NC) |
| 3/19/2010 |
| Miami, Florida | * | |
|
| 3/20/2010 |
| Miami, Florida | * | |
|
| 3/21/2010 |
| Miami, Florida | * | |
|
| 3/23/2010 | at | Davidson |
|
|
|
| 3/26/2010 | at | Boston College | * |
|
|
| 3/27/2010 | at | Boston College | * |
|
|
| 3/28/2010 | at | Boston College | * |
|
|
| 3/30/2010 |
| High Point |
|
|
|
| 3/31/2010 | at | North Carolina Central |
|
|
|
| 3/31/2010 | at | North Carolina Central |
|
|
|
| 4/2/2010 | at | Georgia Tech | * |
|
|
| 4/3/2010 | at | Georgia Tech | * |
|
|
| 4/4/2010 | at | Georgia Tech | * |
|
|
| 4/6/2010 |
| William and Mary |
|
|
|
| 4/9/2010 |
| Clemson | * |
|
|
| 4/10/2010 |
| Clemson | * |
|
|
| 4/11/2010 |
| Clemson | * |
|
|
| 4/13/2010 |
| Davidson |
|
|
|
| 4/14/2010 |
| UNC Greensboro |
|
|
|
| 4/16/2010 |
| Florida State | * |
| Cary, NC |
| 4/17/2010 |
| Florida State | * |
| Cary, NC |
| 4/18/2010 |
| Florida State | * |
| Cary, NC |
| 4/20/2010 | at | Liberty |
|
|
|
| 4/23/2010 | at | Wake Forest | * |
|
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| 4/24/2010 | at | Wake Forest | * |
|
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| 4/25/2010 | at | Wake Forest | * |
|
|
| 4/27/2010 |
| North Carolina A&T |
|
|
|
| 4/28/2010 | at | High Point |
|
|
|
| 4/30/2010 |
| Virginia | * |
|
|
| 5/1/2010 |
| Virginia | * |
|
|
| 5/2/2010 |
| Virginia | * |
|
|
| 5/10/2010 | at | North Carolina A&T |
|
|
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| 5/11/2010 |
| Presbyterian |
|
|
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| 5/14/2010 | at | Virginia Tech | * |
|
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| 5/15/2010 | at | Virginia Tech | * |
|
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| 5/16/2010 | at | Virginia Tech | * |
|
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| 5/20/2010 | at | NC State | * |
|
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| 5/21/2010 | at | NC State | * |
|
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| 5/21/2010 | at | Wofford |
|
| makeup of 3/10 game |
| 5/22/2010 | at | NC State | * |
|
|