| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 5/14/2009 | * | #2 LSU | 5 | at | Mississippi State | 4 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #5 North Carolina | 1 | at | Boston College | 3 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #6 Rice | 5 | at | UAB | 7 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #8 Georgia Tech | 10 | at | Duke | 3 | FINAL | Box Score | Recap | |
| 5/14/2009 |
| Grambling State | 1 | at | #9 Florida State | 8 | FINAL | Box Score | Recap | 6 innings, inclement weather |
| 5/14/2009 | * | #10 Virginia | 4 | at | Virginia Tech | 5 | FINAL | Box Score | Recap | 10 innings |
| 5/14/2009 | * | #11 Mississippi | 7 | at | #17 Arkansas | 5 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Kentucky | 3 | at | #12 Florida | 10 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #14 TCU | 10 | at | UNLV | 4 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #16 Clemson | 13 | at | NC State | 8 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #18 Georgia | 2 | at | South Carolina | 7 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #19 Alabama | 2 | at | Auburn | 3 | FINAL | Box Score | Recap | 10 innings |
| 5/14/2009 | * | Memphis | 4 | at | #20 East Carolina | 9 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #21 Miami, Florida | 23 | at | Wake Forest | 5 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Charleston Southern | 1 | at | #22 Coastal Carolina | 9 | FINAL | Box Score | Recap | 800th career win for CCU's Gary Gilmore |
| 5/14/2009 | * | #27 George Mason | 10 | at | James Madison | 6 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | South Florida | 1 | at | #28 Louisville | 2 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Iowa | 4 | at | #29 Ohio State | 13 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #30 Texas State | 8 | at | UT Arlington | 6 | FINAL | Box Score | Recap | 10 innings |
| Atlantic 10 Conference |
| 5/14/2009 | * | Charlotte | 13 | at | St. Bonaventure | 2 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Dayton | 8 | at | Xavier | 5 | FINAL | Box Score | Recap | 10 innings |
| 5/14/2009 | * | Duquesne |
| at | Massachusetts |
| Postponed | | Recap | PPD to 5/15, rain |
| 5/14/2009 | * | George Washington | 4 | at | St. Joseph's | 5 | FINAL | Box Score | Recap | Camden, NJ |
| 5/14/2009 | * | Rhode Island | 3 | at | St. Louis | 5 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Richmond | 11 | at | LaSalle | 9 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Temple | 6 | at | Fordham | 15 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 5/14/2009 | * | #5 North Carolina | 1 | at | Boston College | 3 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #8 Georgia Tech | 10 | at | Duke | 3 | FINAL | Box Score | Recap | |
| 5/14/2009 |
| Grambling State | 1 | at | #9 Florida State | 8 | FINAL | Box Score | Recap | 6 innings, inclement weather |
| 5/14/2009 | * | #10 Virginia | 4 | at | Virginia Tech | 5 | FINAL | Box Score | Recap | 10 innings |
| 5/14/2009 | * | #16 Clemson | 13 | at | NC State | 8 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #21 Miami, Florida | 23 | at | Wake Forest | 5 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 5/14/2009 | * | Kennesaw State | 6 | at | North Florida | 5 | FINAL | Box Score | Recap | 11 innings |
| 5/14/2009 | * | Lipscomb |
| at | East Tennessee State |
| Suspended | | Recap | Suspended to 5/15, inclement weather (4-3 Lipscomb, bottom 5) |
| 5/14/2009 | * | Mercer | 9 | at | Belmont | 5 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | South Carolina-Upstate | 7 | at | Campbell | 4 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Stetson |
| at | Florida Gulf Coast |
| Postponed | | Recap | PPD to 5/15, inclement weather |
| 5/14/2009 |
| Dallas Baptist | 13 | at | Jacksonville | 1 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 5/14/2009 | * | Iowa | 4 | at | #29 Ohio State | 13 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Illinois | 5 | at | Purdue | 12 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Michigan | 16 | at | Northwestern | 6 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Michigan State | 4 | at | Indiana | 6 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Minnesota | 7 | at | Penn State | 6 | FINAL | Box Score | Recap | 1,000th career win for Minnesota's John Anderson |
| Big East Conference |
| 5/14/2009 | * | South Florida | 1 | at | #28 Louisville | 2 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Connecticut | 20 | at | Villanova | 6 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Georgetown | 2 | at | Rutgers | 7 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Notre Dame | 9 | at | St. John's | 1 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Seton Hall | 4 | at | Cincinnati | 5 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | West Virginia | 1 | at | Pittsburgh | 9 | FINAL | Box Score | Recap | |
| Big South Conference |
| 5/14/2009 | * | Charleston Southern | 1 | at | #22 Coastal Carolina | 9 | FINAL | Box Score | Recap | 800th career win for CCU's Gary Gilmore |
| 5/14/2009 | * | Gardner-Webb | 2 | at | Winthrop | 4 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | High Point |
| at | VMI |
| Suspended | | Recap | Suspended to 5/15, rain (10-1 VMI, top 8) |
| 5/14/2009 | * | Presbyterian | 14 | at | UNC Asheville | 19 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Radford | 8 | at | Liberty | 9 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 5/14/2009 | * | #27 George Mason | 10 | at | James Madison | 6 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Northeastern | 10 | at | Towson | 13 | FINAL | Box Score | Recap | 11 innings |
| 5/14/2009 | * | UNC Wilmington | 17 | at | Old Dominion | 7 | FINAL | Box Score | Recap | UNCW's Bobby Leeper hits for cycle |
| 5/14/2009 | * | VCU | 1 | at | Delaware | 6 | FINAL | Box Score | Recap | |
| Conference USA |
| 5/14/2009 | * | #6 Rice | 5 | at | UAB | 7 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Memphis | 4 | at | #20 East Carolina | 9 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Houston | 4 | at | UCF | 8 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Tulane | 2 | at | Marshall | 9 | FINAL | Box Score | Recap | |
| 5/14/2009 |
| Tennessee Tech |
| at | Southern Mississippi |
| Postponed | | Recap | PPD to 5/15, inclement weather |
| Division I Independents |
| 5/14/2009 |
| Dallas Baptist | 13 | at | Jacksonville | 1 | FINAL | Box Score | Recap | |
| 5/14/2009 |
| Longwood |
| at | Appalachian State |
| Suspended | | Recap | Suspended to 5/15, rain (16-6 ASU, bottom 6) |
| 5/14/2009 |
| Utah Valley State | 2 | at | Hawaii | 7 | FINAL | Box Score | Recap | |
| Horizon League |
| 5/14/2009 | * | Butler | 5 | at | Wisconsin-Milwaukee | 6 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Butler | 6 | at | Wisconsin-Milwaukee | 7 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 5/14/2009 | * | Niagara | 10 | at | Canisius | 11 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Niagara | 8 | at | Canisius | 12 | FINAL | Box Score | Recap | 7 innings |
| 5/14/2009 | * | St. Peter's | 6 | at | Rider | 9 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 5/14/2009 | * | Akron | 9 | at | Bowling Green State | 14 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Buffalo | 5 | at | Ohio | 6 | FINAL | Box Score | Recap | 11 innings |
| 5/14/2009 | * | Central Michigan | 6 | at | Eastern Michigan | 7 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Miami, Ohio | 14 | at | Kent State | 3 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Northern Illinois | 21 | at | Western Michigan | 9 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Toledo | 6 | at | Ball State | 15 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 5/14/2009 | MEAC-03 | UMES | 2 | vs | Florida A&M | 12 | FINAL | Box Score | Recap | MEAC Tournament, Game 3 (Daytona Beach, FL) |
| 5/14/2009 | MEAC-02 | North Carolina A&T | 6 | vs | Delaware State | 4 | FINAL | Box Score | Recap | MEAC Tournament, Game 2 (Daytona Beach, FL) (10 innings) |
| 5/14/2009 | MEAC-01 | Norfolk State | 3 | vs | Bethune-Cookman | 12 | FINAL | Box Score | Recap | MEAC Tournament, Game 1 (Daytona Beach, FL) |
| Missouri Valley Conference |
| 5/14/2009 | * | Bradley | 0 | at | Northern Iowa | 5 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Creighton | 1 | at | Wichita State | 4 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Indiana State | 6 | at | Missouri State | 9 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Southern Illinois | 5 | at | Evansville | 2 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 5/14/2009 | * | #14 TCU | 10 | at | UNLV | 4 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | New Mexico | 25 | at | Air Force | 7 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | San Diego State | 11 | at | Utah | 2 | FINAL | Box Score | Recap | Ogden, UT |
| Northeast Conference |
| 5/14/2009 | * | Quinnipiac | 6 | at | Long Island | 3 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Sacred Heart | 19 | at | Mount St. Mary's | 6 | FINAL | Box Score | Recap | |
| Ohio Valley Conference |
| 5/14/2009 |
| Tennessee Tech |
| at | Southern Mississippi |
| Postponed | | Recap | PPD to 5/15, inclement weather |
| Southeastern Conference |
| 5/14/2009 | * | #2 LSU | 5 | at | Mississippi State | 4 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #11 Mississippi | 7 | at | #17 Arkansas | 5 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Kentucky | 3 | at | #12 Florida | 10 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #18 Georgia | 2 | at | South Carolina | 7 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | #19 Alabama | 2 | at | Auburn | 3 | FINAL | Box Score | Recap | 10 innings |
| 5/14/2009 | * | Tennessee | 8 | at | Vanderbilt | 6 | FINAL | Box Score | Recap | |
| Southern Conference |
| 5/14/2009 | * | College of Charleston | 3 | at | The Citadel | 14 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | UNC Greensboro | 2 | at | Furman | 3 | FINAL | Box Score | Recap | 11 innings |
| 5/14/2009 | * | Western Carolina | 10 | at | Davidson | 8 | FINAL | Box Score | Recap | 12 innings |
| 5/14/2009 |
| Longwood |
| at | Appalachian State |
| Suspended | | Recap | Suspended to 5/15, rain (16-6 ASU, bottom 6) |
| Southland Conference |
| 5/14/2009 | * | #30 Texas State | 8 | at | UT Arlington | 6 | FINAL | Box Score | Recap | 10 innings |
| 5/14/2009 | * | Central Arkansas | 14 | at | UTSA | 15 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Lamar | 9 | at | Stephen F. Austin | 3 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | McNeese State |
| at | Nicholls State |
| Postponed | | Recap | PPD to 5/15, rain and field conditions |
| 5/14/2009 | * | Southeastern Louisiana | 4 | at | Northwestern State | 12 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Texas A&M-Corpus Christi | 2 | at | Sam Houston State | 10 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 5/14/2009 |
| Grambling State | 1 | at | #9 Florida State | 8 | FINAL | Box Score | Recap | 6 innings, inclement weather |
| Summit League |
| 5/14/2009 | * | IUPU-Fort Wayne | 7 | at | North Dakota State | 3 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Oakland | 4 | at | Centenary | 6 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Oral Roberts | 31 | at | Western Illinois | 3 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Southern Utah | 9 | at | South Dakota State | 7 | FINAL | Box Score | Recap | 10 innings |
| Sun Belt Conference |
| 5/14/2009 | * | Arkansas State |
| at | Arkansas-Little Rock |
| Postponed | | Recap | PPD to 5/15, field conditions |
| 5/14/2009 | * | Florida International | 5 | at | Florida Atlantic | 9 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Louisiana-Lafayette | 10 | at | New Orleans | 4 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Troy | 5 | at | South Alabama | 6 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | Western Kentucky | 4 | at | Middle Tennessee State | 10 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 5/14/2009 | * | Fresno State | 15 | at | Sacramento State | 7 | FINAL | Box Score | Recap | 500th career win for Fresno St's Mike Batesole |
| 5/14/2009 | * | New Mexico State | 5 | at | Louisiana Tech | 6 | FINAL | Box Score | Recap | |
| 5/14/2009 | * | New Mexico State | 16 | at | Louisiana Tech | 0 | FINAL | Box Score | Recap | 7 innings |
| 5/14/2009 |
| Utah Valley State | 2 | at | Hawaii | 7 | FINAL | Box Score | Recap | |