| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/25/2009 | * | Maryland | 3 | at | #1 North Carolina | 14 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #30 Kansas State | 5 | at | #2 Texas | 4 | FINAL | Box Score | Recap | 12 innings |
| 4/25/2009 | * | #3 Arizona State | 6 | at | California | 10 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #4 Georgia | 8 | at | #11 Mississippi | 10 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| #6 UC Irvine | 3 | at | Utah | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Auburn | 6 | at | #7 LSU | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #8 Georgia Tech | 5 | at | #21 Clemson | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #9 Cal State Fullerton | 3 | at | UC Davis | 0 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Wake Forest | 4 | at | #10 Florida State | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Virginia Tech | 7 | at | #12 Miami, Florida | 4 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #13 Arkansas | 4 | at | Tennessee | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #14 Oklahoma | 12 | at | #15 Baylor | 4 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | NC State | 3 | at | #16 Virginia | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #17 Cal Poly | 6 | at | UC Santa Barbara | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #25 Oklahoma State | 4 | at | #18 Texas A&M | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #19 Coastal Carolina | 5 | at | Presbyterian | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #20 TCU | 8 | at | San Diego State | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | South Carolina | 3 | at | #22 Florida | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Northwestern | 7 | at | #23 Ohio State | 11 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Southern Mississippi | 5 | at | #24 East Carolina | 13 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Southern Mississippi | 2 | at | #24 East Carolina | 1 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #26 Oregon State | 5 | at | UCLA | 3 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Kentucky | 11 | at | #27 Alabama | 1 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Portland | 3 | at | #28 San Diego | 13 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #29 Georgia Southern | 3 | at | The Citadel | 1 | FINAL | Box Score | Recap | |
| America East Conference |
| 4/25/2009 | * | Albany | 5 | at | Stony Brook | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Albany | 3 | at | Stony Brook | 16 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Hartford | 5 | at | UMBC | 10 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Hartford | 4 | at | UMBC | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Vermont | 8 | at | Maine | 11 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Vermont | 5 | at | Maine | 4 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| New Jersey Tech | 2 | at | Binghamton | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| New Jersey Tech | 1 | at | Binghamton | 25 | FINAL | Box Score | Recap | 7 innings |
| Atlantic 10 Conference |
| 4/25/2009 | * | Charlotte | 10 | at | St. Louis | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Dayton | 16 | at | Fordham | 9 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | George Washington | 6 | at | Duquesne | 13 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Massachusetts | 5 | at | LaSalle | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Rhode Island | 14 | at | St. Joseph's | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Richmond | 5 | at | St. Bonaventure | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Xavier | 14 | at | Temple | 9 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/25/2009 | * | Maryland | 3 | at | #1 North Carolina | 14 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #8 Georgia Tech | 5 | at | #21 Clemson | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Wake Forest | 4 | at | #10 Florida State | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Virginia Tech | 7 | at | #12 Miami, Florida | 4 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | NC State | 3 | at | #16 Virginia | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Boston College | 2 | at | Duke | 9 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 4/25/2009 | * | Kennesaw State | 7 | at | Belmont | 3 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Lipscomb | 2 | at | Jacksonville | 12 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Mercer | 0 | at | North Florida | 10 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Mercer | 6 | at | North Florida | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | South Carolina-Upstate | 3 | at | Florida Gulf Coast | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | South Carolina-Upstate | 4 | at | Florida Gulf Coast | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Stetson | 8 | at | Campbell | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| High Point | 15 | at | East Tennessee State | 17 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 4/25/2009 | * | Northwestern | 7 | at | #23 Ohio State | 11 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Illinois | 11 | at | Penn State | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Indiana | 8 | at | Michigan | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Michigan State | 15 | at | Iowa | 4 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Purdue | 1 | at | Minnesota | 3 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 4/25/2009 | * | #30 Kansas State | 5 | at | #2 Texas | 4 | FINAL | Box Score | Recap | 12 innings |
| 4/25/2009 | * | #14 Oklahoma | 12 | at | #15 Baylor | 4 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #25 Oklahoma State | 4 | at | #18 Texas A&M | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Nebraska |
| at | Kansas |
| Postponed | | Recap | PPD to 4/26, inclement weather |
| 4/25/2009 | * | Texas Tech | 5 | at | Missouri | 9 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/25/2009 | * | Georgetown | 0 | at | Seton Hall | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Notre Dame | 11 | at | Louisville | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Rutgers | 14 | at | Pittsburgh | 10 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Rutgers | 6 | at | Pittsburgh | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | St. John's | 8 | at | Connecticut | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Villanova | 8 | at | Cincinnati | 9 | FINAL | Box Score | Recap | 10 innings |
| 4/25/2009 | * | West Virginia | 2 | at | South Florida | 11 | FINAL | Box Score | Recap | |
| Big South Conference |
| 4/25/2009 | * | #19 Coastal Carolina | 5 | at | Presbyterian | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Liberty | 10 | at | Gardner-Webb | 2 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Radford | 2 | at | Charleston Southern | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Radford | 1 | at | Charleston Southern | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | VMI | 6 | at | Winthrop | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| College of Charleston | 7 | at | UNC Asheville | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| College of Charleston | 9 | at | UNC Asheville | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| High Point | 15 | at | East Tennessee State | 17 | FINAL | Box Score | Recap | |
| Big West Conference |
| 4/25/2009 |
| #6 UC Irvine | 3 | at | Utah | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #9 Cal State Fullerton | 3 | at | UC Davis | 0 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #17 Cal Poly | 6 | at | UC Santa Barbara | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Long Beach State | 19 | at | Pacific | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | UC Riverside | 5 | at | Cal State Northridge | 4 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/25/2009 | * | Georgia State | 6 | at | James Madison | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Hofstra | 3 | at | George Mason | 10 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | UNC Wilmington | 2 | at | Towson | 3 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | VCU | 6 | at | Northeastern | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | William and Mary | 6 | at | Old Dominion | 5 | FINAL | Box Score | Recap | |
| Conference USA |
| 4/25/2009 | * | Southern Mississippi | 5 | at | #24 East Carolina | 13 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Southern Mississippi | 2 | at | #24 East Carolina | 1 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Houston | 12 | at | Marshall | 4 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Memphis | 8 | at | Tulane | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/25/2009 | * | UCF | 8 | at | UAB | 12 | FINAL | Box Score | Recap | |
| Division I Independents |
| 4/25/2009 |
| Bryant | 3 | at | LeMoyne | 4 | FINAL | Box Score | Recap | 10 innings |
| 4/25/2009 |
| Bryant | 3 | at | LeMoyne | 10 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| Cal State Bakersfield | 4 | at | Nevada | 9 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| Houston Baptist | 4 | at | Arkansas-Little Rock | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| Houston Baptist | 5 | at | Arkansas-Little Rock | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| New Jersey Tech | 2 | at | Binghamton | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| New Jersey Tech | 1 | at | Binghamton | 25 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| New York Tech | 16 | at | Niagara | 9 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| New York Tech | 12 | at | Niagara | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| Northern Colorado | 2 | at | Dallas Baptist | 13 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| Savannah State | 12 | at | Norfolk State | 13 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| Savannah State | 2 | at | Norfolk State | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| Southern Illinois-Edwardsville | 0 | at | Eastern Illinois | 10 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| Southern Illinois-Edwardsville | 2 | at | Eastern Illinois | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| UT Pan American | 10 | at | Prairie View A&M | 11 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| UT Pan American | 7 | at | Prairie View A&M | 5 | FINAL | Box Score | Recap | 7 innings |
| Horizon League |
| 4/25/2009 | * | Cleveland State | 10 | at | Butler | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Cleveland State | 6 | at | Butler | 12 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Valparaiso | 12 | at | Illinois-Chicago | 14 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Valparaiso |
| at | Illinois-Chicago |
| Canceled | | Recap | CCD, inclement weather |
| 4/25/2009 | * | Youngstown State |
| at | Wisconsin-Milwaukee |
| Postponed | | Recap | PPD, field conditions |
| 4/25/2009 | * | Youngstown State |
| at | Wisconsin-Milwaukee |
| Postponed | | Recap | PPD, field conditions |
| Ivy League |
| 4/25/2009 | * | Brown | 3 | at | Yale | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Brown | 2 | at | Yale | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Harvard | 2 | at | Dartmouth | 14 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Harvard | 6 | at | Dartmouth | 4 | FINAL | Box Score | Recap | 10 innings |
| 4/25/2009 | * | Pennsylvania | 5 | at | Columbia | 13 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Pennsylvania | 11 | at | Columbia | 7 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 4/25/2009 | * | Canisius | 4 | at | Manhattan | 11 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Canisius | 9 | at | Manhattan | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Fairfield | 4 | at | Rider | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Fairfield | 13 | at | Rider | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Marist | 6 | at | Siena | 10 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Marist | 8 | at | Siena | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | St. Peter's | 0 | at | Iona | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | St. Peter's | 6 | at | Iona | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| New York Tech | 16 | at | Niagara | 9 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| New York Tech | 12 | at | Niagara | 3 | FINAL | Box Score | Recap | 7 innings |
| Mid American Conference |
| 4/25/2009 | * | Buffalo | 1 | at | Akron | 4 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Kent State | 28 | at | Ohio | 16 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Miami, Ohio | 10 | at | Bowling Green State | 15 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Northern Illinois | 7 | at | Eastern Michigan | 11 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Toledo |
| at | Central Michigan |
| Postponed | | Recap | PPD to 4/26, inclement weather |
| 4/25/2009 | * | Western Michigan | 20 | at | Ball State | 10 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 4/25/2009 | * | Bethune-Cookman | 12 | at | UMES | 2 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Bethune-Cookman | 15 | at | UMES | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Florida A&M | 9 | at | Coppin State | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Florida A&M | 10 | at | Coppin State | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | North Carolina A&T | 2 | at | Delaware State | 3 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | North Carolina A&T | 7 | at | Delaware State | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| Savannah State | 12 | at | Norfolk State | 13 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| Savannah State | 2 | at | Norfolk State | 8 | FINAL | Box Score | Recap | 7 innings |
| Missouri Valley Conference |
| 4/25/2009 | * | Bradley | 0 | at | Creighton | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Illinois State | 6 | at | Southern Illinois | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Missouri State | 14 | at | Evansville | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Wichita State | 10 | at | Northern Iowa | 7 | FINAL | Box Score | Recap | Resumption of 4/24 game |
| 4/25/2009 | * | Wichita State | 6 | at | Northern Iowa | 3 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| Indiana State | 10 | at | Southern Indiana | 0 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 4/25/2009 |
| #6 UC Irvine | 3 | at | Utah | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #20 TCU | 8 | at | San Diego State | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | New Mexico | 11 | at | BYU | 12 | FINAL | Box Score | Recap | Resumption of 4/24 game |
| 4/25/2009 | * | New Mexico |
| at | BYU |
| Canceled | | Recap | CCD, inclement weather |
| 4/25/2009 | * | UNLV | 20 | at | Air Force | 13 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/25/2009 | * | Central Connecticut State | 6 | at | Long Island | 2 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Central Connecticut State | 9 | at | Long Island | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Mount St. Mary's | 4 | at | Wagner | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Mount St. Mary's | 6 | at | Wagner | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Quinnipiac | 9 | at | Fairleigh Dickinson | 10 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Quinnipiac | 18 | at | Fairleigh Dickinson | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Sacred Heart | 4 | at | Monmouth | 10 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Sacred Heart | 10 | at | Monmouth | 3 | FINAL | Box Score | Recap | 7 innings |
| Ohio Valley Conference |
| 4/25/2009 | * | Eastern Kentucky | 3 | at | Jacksonville State | 13 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Eastern Kentucky | 3 | at | Jacksonville State | 14 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Murray State | 13 | at | Morehead State | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Murray State | 9 | at | Morehead State | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Southeast Missouri State | 12 | at | Austin Peay State | 9 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Southeast Missouri State | 5 | at | Austin Peay State | 9 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Tennessee-Martin | 21 | at | Tennessee Tech | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Tennessee-Martin | 0 | at | Tennessee Tech | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 |
| Southern Illinois-Edwardsville | 0 | at | Eastern Illinois | 10 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| Southern Illinois-Edwardsville | 2 | at | Eastern Illinois | 4 | FINAL | Box Score | Recap | 7 innings |
| Pac 10 Conference |
| 4/25/2009 | * | #3 Arizona State | 6 | at | California | 10 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #26 Oregon State | 5 | at | UCLA | 3 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Arizona | 1 | at | Stanford | 3 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Washington | 2 | at | Oregon | 0 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Washington State | 13 | at | Southern California | 3 | FINAL | Box Score | Recap | |
| Patriot League |
| 4/25/2009 | * | Army | 12 | at | Lafayette | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Army | 8 | at | Lafayette | 14 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Bucknell | 7 | at | Lehigh | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Bucknell | 10 | at | Lehigh | 11 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Navy | 8 | at | Holy Cross | 13 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Navy | 12 | at | Holy Cross | 11 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 4/25/2009 | * | #4 Georgia | 8 | at | #11 Mississippi | 10 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Auburn | 6 | at | #7 LSU | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | #13 Arkansas | 4 | at | Tennessee | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | South Carolina | 3 | at | #22 Florida | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Kentucky | 11 | at | #27 Alabama | 1 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Mississippi State | 4 | at | Vanderbilt | 10 | FINAL | Box Score | Recap | |
| Southern Conference |
| 4/25/2009 | * | #29 Georgia Southern | 3 | at | The Citadel | 1 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Elon | 12 | at | Samford | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | UNC Greensboro | 2 | at | Davidson | 4 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Western Carolina | 10 | at | Furman | 11 | FINAL | Box Score | Recap | 15 innings |
| 4/25/2009 | * | Wofford | 0 | at | Appalachian State | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| College of Charleston | 7 | at | UNC Asheville | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| College of Charleston | 9 | at | UNC Asheville | 3 | FINAL | Box Score | Recap | 7 innings |
| Southland Conference |
| 4/25/2009 | * | Central Arkansas | 7 | at | Texas A&M-Corpus Christi | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | McNeese State | 6 | at | Texas State | 16 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/25/2009 | * | Northwestern State | 1 | at | Lamar | 6 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Southeastern Louisiana | 7 | at | Sam Houston State | 5 | FINAL | Box Score | Recap | 10 innings |
| 4/25/2009 | * | UT Arlington | 2 | at | Stephen F. Austin | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | UTSA | 9 | at | Nicholls State | 4 | FINAL | Box Score | Recap | 12 innings |
| Southwestern Athletic Conference |
| 4/25/2009 | * | Alabama A&M | 3 | at | Alabama State | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Arkansas-Pine Bluff | 7 | at | Grambling State | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Arkansas-Pine Bluff | 5 | at | Grambling State | 4 | FINAL | Box Score | Recap | 8 innings |
| 4/25/2009 | * | Mississippi Valley State | 7 | at | Jackson State | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Texas Southern | 1 | at | Southern | 4 | FINAL | Box Score | | 7 innings |
| 4/25/2009 | * | Texas Southern | 7 | at | Southern | 1 | FINAL | Box Score | | 7 innings |
| 4/25/2009 |
| Alcorn State | 19 | at | Concordia (AL) | 0 | FINAL | Box Score | | 5 innings |
| 4/25/2009 |
| Alcorn State | 9 | at | Concordia (AL) | 1 | FINAL | Box Score | | 7 innings |
| 4/25/2009 |
| UT Pan American | 10 | at | Prairie View A&M | 11 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| UT Pan American | 7 | at | Prairie View A&M | 5 | FINAL | Box Score | Recap | 7 innings |
| Summit League |
| 4/25/2009 | * | IUPU-Fort Wayne | 9 | at | Centenary | 15 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | IUPU-Fort Wayne | 3 | at | Centenary | 7 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Oakland | 8 | at | Southern Utah | 7 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Oakland | 7 | at | Southern Utah | 6 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Oral Roberts | 2 | at | North Dakota State | 3 | FINAL | Box Score | Recap | 10 innings |
| 4/25/2009 | * | Oral Roberts | 5 | at | North Dakota State | 0 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | South Dakota State | 16 | at | Western Illinois | 13 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | South Dakota State | 14 | at | Western Illinois | 7 | FINAL | Box Score | Recap | 7 innings |
| Sun Belt Conference |
| 4/25/2009 | * | Arkansas State | 6 | at | New Orleans | 13 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Florida Atlantic | 3 | at | Western Kentucky | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Florida International | 8 | at | Louisiana-Monroe | 3 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Louisiana-Lafayette | 6 | at | Troy | 2 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Middle Tennessee State | 14 | at | South Alabama | 1 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| Houston Baptist | 4 | at | Arkansas-Little Rock | 5 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| Houston Baptist | 5 | at | Arkansas-Little Rock | 2 | FINAL | Box Score | Recap | 7 innings |
| West Coast Conference |
| 4/25/2009 | * | Portland | 3 | at | #28 San Diego | 13 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Gonzaga | 12 | at | Santa Clara | 10 | FINAL | Box Score | Recap | 11 innings |
| 4/25/2009 | * | Loyola Marymount | 6 | at | St. Mary's | 13 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Pepperdine | 7 | at | San Francisco | 6 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 4/25/2009 | * | Fresno State | 8 | at | San Jose State | 2 | FINAL | Box Score | Recap | |
| 4/25/2009 | * | Fresno State | 0 | at | San Jose State | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2009 | * | Hawaii | 6 | at | New Mexico State | 16 | FINAL | Box Score | Recap | 8 innings, run rule |
| 4/25/2009 | * | Hawaii | 8 | at | New Mexico State | 7 | FINAL | Box Score | Recap | 10 innings |
| 4/25/2009 | * | Louisiana Tech | 6 | at | Sacramento State | 8 | FINAL | Box Score | Recap | |
| 4/25/2009 |
| Cal State Bakersfield | 4 | at | Nevada | 9 | FINAL | Box Score | Recap | |