| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/21/2009 |
| UNC Wilmington | 5 | at | #1 North Carolina | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #5 Rice | 7 | at | #2 Texas | 4 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Hawaii | 2 | at | #3 Arizona State | 17 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Kennesaw State | 7 | at | #4 Georgia | 11 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Oregon | 4 | at | #6 UC Irvine | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Southeastern Louisiana | 5 | at | #7 LSU | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Western Carolina | 7 | at | #8 Georgia Tech | 16 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #28 San Diego | 5 | at | #9 Cal State Fullerton | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UNC Asheville | 2 | at | #10 Florida State | 9 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Arkansas-Little Rock | 1 | at | #11 Mississippi | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #13 Arkansas | 9 | at | Oral Roberts | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #15 Baylor | 8 | at | Sam Houston State | 9 | FINAL | Box Score | Recap | makeup of 3/24 game |
| 4/21/2009 |
| #16 Virginia | 8 | at | VCU | 1 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #19 Coastal Carolina | 3 | at | #21 Clemson | 5 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Texas A&M-Corpus Christi | 2 | at | #20 TCU | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #22 Florida | 12 | at | Florida Gulf Coast | 3 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Bowling Green State |
| at | #23 Ohio State |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Elon | 9 | at | #24 East Carolina | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #25 Oklahoma State | 4 | at | Wichita State | 1 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Charleston Southern | 1 | at | #29 Georgia Southern | 12 | FINAL | Box Score | Recap | |
| America East Conference |
| 4/21/2009 |
| Stony Brook |
| at | Hofstra |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| UMBC | 9 | at | Georgetown | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Binghamton | 2 | at | Army | 5 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Dartmouth | 13 | at | Vermont | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Holy Cross |
| at | Maine |
| Postponed | | Recap | PPD to 4/29, rain (Sanford, ME) |
| 4/21/2009 |
| LeMoyne | 6 | at | Albany | 8 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 4/21/2009 |
| Niagara |
| at | Duquesne |
| Canceled | | Recap | CCD, inclement weather |
| 4/21/2009 |
| Sacred Heart | 4 | at | Rhode Island | 7 | FINAL | Box Score | Recap | 6 innings, rain |
| 4/21/2009 |
| Shawnee State | 6 | at | Dayton | 13 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| St. Louis | 6 | at | Eastern Illinois | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Villanova | 6 | at | Temple | 15 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Winthrop | 7 | at | Charlotte | 2 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Xavier | 6 | at | Eastern Kentucky | 11 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Canisius |
| at | St. Bonaventure |
| Canceled | | Recap | CCD, inclement weather |
| 4/21/2009 |
| George Washington | 2 | at | George Mason | 11 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Iona | 3 | at | Fordham | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| LaSalle | 5 | at | Maryland | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Massachusetts |
| at | Central Connecticut State |
| Postponed | | Recap | PPD, inclement weather |
| Atlantic Coast Conference |
| 4/21/2009 |
| NC State | 3 | at | UNC Greensboro | 5 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Wake Forest | 5 | at | High Point | 12 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| William and Mary | 14 | at | Virginia Tech | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UNC Wilmington | 5 | at | #1 North Carolina | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Western Carolina | 7 | at | #8 Georgia Tech | 16 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UNC Asheville | 2 | at | #10 Florida State | 9 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #16 Virginia | 8 | at | VCU | 1 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #19 Coastal Carolina | 3 | at | #21 Clemson | 5 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Bryant | 8 | at | Boston College | 16 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| LaSalle | 5 | at | Maryland | 6 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 4/21/2009 |
| North Carolina Central | 5 | at | Campbell | 15 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2009 |
| North Carolina Central | 0 | at | Campbell | 18 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2009 |
| South Carolina | 14 | at | South Carolina-Upstate | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Stetson | 12 | at | UCF | 13 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Kennesaw State | 7 | at | #4 Georgia | 11 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #22 Florida | 12 | at | Florida Gulf Coast | 3 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| East Tennessee State | 9 | at | Tennessee | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Lambuth | 3 | at | Belmont | 5 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Lipscomb | 8 | at | Kentucky | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Mercer | 16 | at | Florida A&M | 5 | FINAL | Box Score | Recap | 7 innings |
| Big 10 Conference |
| 4/21/2009 |
| Notre Dame |
| at | Michigan |
| Postponed | | Recap | PPD to 4/22, inclement weather |
| 4/21/2009 |
| Purdue |
| vs | Valparaiso |
| Canceled | | Recap | CCD, rain (Gary, IN) |
| 4/21/2009 |
| Western Illinois | 7 | vs | Iowa | 20 | FINAL | Box Score | Recap | Davenport, IA |
| 4/21/2009 |
| Bowling Green State |
| at | #23 Ohio State |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Illinois Tech |
| at | Northwestern |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Louisville | 10 | at | Indiana | 8 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 4/21/2009 |
| Nebraska | 4 | at | Creighton | 3 | FINAL | Box Score | Recap | 12 innings |
| 4/21/2009 |
| UNLV | 6 | at | Texas Tech | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #5 Rice | 7 | at | #2 Texas | 4 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #15 Baylor | 8 | at | Sam Houston State | 9 | FINAL | Box Score | Recap | makeup of 3/24 game |
| 4/21/2009 |
| #25 Oklahoma State | 4 | at | Wichita State | 1 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Baker | 2 | at | Kansas | 11 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/21/2009 |
| New York Tech | 2 | at | Seton Hall | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Notre Dame |
| at | Michigan |
| Postponed | | Recap | PPD to 4/22, inclement weather |
| 4/21/2009 |
| Princeton |
| at | St. John's |
| Postponed | | Recap | PPD, field conditions |
| 4/21/2009 |
| UMBC | 9 | at | Georgetown | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Villanova | 6 | at | Temple | 15 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Fairfield |
| at | Connecticut |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Louisville | 10 | at | Indiana | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Morehead State | 5 | at | Cincinnati | 10 | FINAL | Box Score | Recap | |
| Big South Conference |
| 4/21/2009 |
| VMI | 2 | at | Old Dominion | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/21/2009 |
| Wake Forest | 5 | at | High Point | 12 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Winthrop | 7 | at | Charlotte | 2 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Wofford | 9 | at | Presbyterian | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UNC Asheville | 2 | at | #10 Florida State | 9 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #19 Coastal Carolina | 3 | at | #21 Clemson | 5 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Charleston Southern | 1 | at | #29 Georgia Southern | 12 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Davidson | 6 | at | Radford | 12 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Gardner-Webb | 3 | at | Furman | 4 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Liberty |
| at | Longwood |
| Postponed | | Recap | PPD, inclement weather |
| Big West Conference |
| 4/21/2009 |
| Pacific | 10 | at | Nevada | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Pepperdine | 8 | at | Cal State Northridge | 9 | FINAL | Box Score | Recap | 11 innings |
| 4/21/2009 |
| St. Mary's | 7 | at | UC Davis | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UC Santa Barbara | 17 | at | Cal State Bakersfield | 2 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UCLA | 6 | at | UC Riverside | 17 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Oregon | 4 | at | #6 UC Irvine | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #28 San Diego | 5 | at | #9 Cal State Fullerton | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Long Beach State | 3 | at | San Diego State | 6 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/21/2009 |
| Stony Brook |
| at | Hofstra |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Towson |
| at | Mount St. Mary's |
| Postponed | | Recap | PPD to 4/22, rain |
| 4/21/2009 |
| VMI | 2 | at | Old Dominion | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/21/2009 |
| William and Mary | 14 | at | Virginia Tech | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UNC Wilmington | 5 | at | #1 North Carolina | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #16 Virginia | 8 | at | VCU | 1 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Delaware |
| at | Delaware State |
| Postponed | | Recap | PPD to 4/22, field conditions |
| 4/21/2009 |
| George Washington | 2 | at | George Mason | 11 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Georgia State | 9 | at | Tennessee Tech | 7 | FINAL | Box Score | Recap | |
| Conference USA |
| 4/21/2009 |
| Ohio |
| at | Marshall |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Stephen F. Austin | 11 | at | Houston | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Stetson | 12 | at | UCF | 13 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Tulane | 8 | at | New Orleans | 3 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UAB | 3 | at | Troy | 11 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #5 Rice | 7 | at | #2 Texas | 4 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Elon | 9 | at | #24 East Carolina | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Memphis | 7 | at | Murray State | 13 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Mississippi Valley State | 5 | at | Southern Mississippi | 13 | FINAL | Box Score | Recap | |
| Division I Independents |
| 4/21/2009 |
| New York Tech | 2 | at | Seton Hall | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| North Carolina Central | 5 | at | Campbell | 15 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2009 |
| North Carolina Central | 0 | at | Campbell | 18 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2009 |
| Northern Colorado | 3 | at | Air Force | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| South Carolina-Beaufort | 12 | at | Savannah State | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Southern Utah | 7 | at | Utah Valley State | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UC Santa Barbara | 17 | at | Cal State Bakersfield | 2 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UTSA | 16 | at | UT Pan American | 5 | FINAL | Box Score | Recap | UTSA's Lance Brown hits for cycle |
| 4/21/2009 |
| Bryant | 8 | at | Boston College | 16 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Central Missouri | 4 | at | Southern Illinois-Edwardsville | 2 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Chicago State |
| at | Wisconsin-Milwaukee |
| Postponed | | Recap | PPD, weather and field conditions |
| 4/21/2009 |
| Chicago State |
| at | Wisconsin-Milwaukee |
| Postponed | | Recap | PPD, weather and field conditions |
| 4/21/2009 |
| Dallas Baptist | 15 | at | Central Arkansas | 1 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Houston Baptist | 2 | at | Texas Southern | 15 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| LeMoyne | 6 | at | Albany | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Liberty |
| at | Longwood |
| Postponed | | Recap | PPD, inclement weather |
| Horizon League |
| 4/21/2009 |
| Northern Illinois |
| at | Illinois-Chicago |
| Canceled | | Recap | CCD, impending weather |
| 4/21/2009 |
| Purdue |
| vs | Valparaiso |
| Canceled | | Recap | CCD, rain (Gary, IN) |
| 4/21/2009 |
| Toledo |
| at | Cleveland State |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Chicago State |
| at | Wisconsin-Milwaukee |
| Postponed | | Recap | PPD, weather and field conditions |
| 4/21/2009 |
| Chicago State |
| at | Wisconsin-Milwaukee |
| Postponed | | Recap | PPD, weather and field conditions |
| Ivy League |
| 4/21/2009 |
| Princeton |
| at | St. John's |
| Postponed | | Recap | PPD, field conditions |
| 4/21/2009 |
| Cornell | 15 | at | Siena | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2009 |
| Cornell | 4 | at | Siena | 7 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2009 |
| Dartmouth | 13 | at | Vermont | 10 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 4/21/2009 |
| Niagara |
| at | Duquesne |
| Canceled | | Recap | CCD, inclement weather |
| 4/21/2009 |
| Canisius |
| at | St. Bonaventure |
| Canceled | | Recap | CCD, inclement weather |
| 4/21/2009 |
| Cornell | 15 | at | Siena | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2009 |
| Cornell | 4 | at | Siena | 7 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2009 |
| Fairfield |
| at | Connecticut |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Iona | 3 | at | Fordham | 8 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 4/21/2009 |
| Northern Illinois |
| at | Illinois-Chicago |
| Canceled | | Recap | CCD, impending weather |
| 4/21/2009 |
| Ohio |
| at | Marshall |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Toledo |
| at | Cleveland State |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Bowling Green State |
| at | #23 Ohio State |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Central Michigan |
| at | Oakland |
| Canceled | | Recap | CCD, rain |
| 4/21/2009 |
| Malone | 4 | at | Akron | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Miami, Ohio |
| at | Indiana State |
| Canceled | | Recap | CCD, rain |
| Mid-Eastern Athletic Conference |
| 4/21/2009 |
| North Carolina A&T | 6 | at | Appalachian State | 9 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UMES | 6 | at | Navy | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Delaware |
| at | Delaware State |
| Postponed | | Recap | PPD to 4/22, field conditions |
| 4/21/2009 |
| Florida Atlantic | 5 | at | Bethune-Cookman | 4 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Mercer | 16 | at | Florida A&M | 5 | FINAL | Box Score | Recap | 7 innings |
| Missouri Valley Conference |
| 4/21/2009 |
| Nebraska | 4 | at | Creighton | 3 | FINAL | Box Score | Recap | 12 innings |
| 4/21/2009 |
| #25 Oklahoma State | 4 | at | Wichita State | 1 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Evansville | 4 | at | Southeast Missouri State | 9 | FINAL | Box Score | Recap | makeup of 3/31 game |
| 4/21/2009 |
| Miami, Ohio |
| at | Indiana State |
| Canceled | | Recap | CCD, rain |
| Mountain West Conference |
| 4/21/2009 |
| Northern Colorado | 3 | at | Air Force | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UNLV | 6 | at | Texas Tech | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Washington State | 13 | at | Utah | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Texas A&M-Corpus Christi | 2 | at | #20 TCU | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Long Beach State | 3 | at | San Diego State | 6 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/21/2009 |
| Sacred Heart | 4 | at | Rhode Island | 7 | FINAL | Box Score | Recap | 6 innings, rain |
| 4/21/2009 |
| Towson |
| at | Mount St. Mary's |
| Postponed | | Recap | PPD to 4/22, rain |
| 4/21/2009 |
| Massachusetts |
| at | Central Connecticut State |
| Postponed | | Recap | PPD, inclement weather |
| Ohio Valley Conference |
| 4/21/2009 |
| St. Louis | 6 | at | Eastern Illinois | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Vanderbilt | 8 | at | Austin Peay State | 9 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Xavier | 6 | at | Eastern Kentucky | 11 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Arkansas State | 2 | at | Tennessee-Martin | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Evansville | 4 | at | Southeast Missouri State | 9 | FINAL | Box Score | Recap | makeup of 3/31 game |
| 4/21/2009 |
| Georgia State | 9 | at | Tennessee Tech | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Memphis | 7 | at | Murray State | 13 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Morehead State | 5 | at | Cincinnati | 10 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 4/21/2009 |
| Portland | 5 | at | Washington | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Southern California | 13 | at | Loyola Marymount | 5 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UCLA | 6 | at | UC Riverside | 17 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Washington State | 13 | at | Utah | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Hawaii | 2 | at | #3 Arizona State | 17 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Oregon | 4 | at | #6 UC Irvine | 7 | FINAL | Box Score | Recap | |
| Patriot League |
| 4/21/2009 |
| UMES | 6 | at | Navy | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Binghamton | 2 | at | Army | 5 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| East Stroudsburg |
| at | Lafayette |
| Canceled | | Recap | CCD, weather and field conditions (makeup of 3/11 game) |
| 4/21/2009 |
| Holy Cross |
| at | Maine |
| Postponed | | Recap | PPD to 4/29, rain (Sanford, ME) |
| 4/21/2009 |
| Muhlenberg |
| at | Lehigh |
| Canceled | | Recap | CCD, inclement weather |
| Southeastern Conference |
| 4/21/2009 |
| Samford | 8 | at | Auburn | 2 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| South Carolina | 14 | at | South Carolina-Upstate | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Vanderbilt | 8 | at | Austin Peay State | 9 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Kennesaw State | 7 | at | #4 Georgia | 11 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Southeastern Louisiana | 5 | at | #7 LSU | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Arkansas-Little Rock | 1 | at | #11 Mississippi | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #13 Arkansas | 9 | at | Oral Roberts | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #22 Florida | 12 | at | Florida Gulf Coast | 3 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| East Tennessee State | 9 | at | Tennessee | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Lipscomb | 8 | at | Kentucky | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Middle Tennessee State | 10 | at | Mississippi State | 6 | FINAL | Box Score | Recap | |
| Southern Conference |
| 4/21/2009 |
| NC State | 3 | at | UNC Greensboro | 5 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| North Carolina A&T | 6 | at | Appalachian State | 9 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Samford | 8 | at | Auburn | 2 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Wofford | 9 | at | Presbyterian | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Western Carolina | 7 | at | #8 Georgia Tech | 16 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Elon | 9 | at | #24 East Carolina | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Charleston Southern | 1 | at | #29 Georgia Southern | 12 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Davidson | 6 | at | Radford | 12 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Gardner-Webb | 3 | at | Furman | 4 | FINAL | Box Score | Recap | |
| Southland Conference |
| 4/21/2009 |
| Northwestern State | 10 | at | Centenary | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Northwood | 7 | at | UT Arlington | 23 | FINAL | Box Score | Recap | UTA's Michael Choice hits for cycle |
| 4/21/2009 |
| South Alabama | 11 | at | Nicholls State | 2 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Stephen F. Austin | 11 | at | Houston | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UTSA | 16 | at | UT Pan American | 5 | FINAL | Box Score | Recap | UTSA's Lance Brown hits for cycle |
| 4/21/2009 |
| Southeastern Louisiana | 5 | at | #7 LSU | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #15 Baylor | 8 | at | Sam Houston State | 9 | FINAL | Box Score | Recap | makeup of 3/24 game |
| 4/21/2009 |
| Texas A&M-Corpus Christi | 2 | at | #20 TCU | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Dallas Baptist | 15 | at | Central Arkansas | 1 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| McNeese State | 2 | at | Louisiana-Monroe | 8 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 4/21/2009 |
| Albany State | 14 | at | Alabama State | 12 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Grambling State | 5 | at | Jackson State | 11 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Houston Baptist | 2 | at | Texas Southern | 15 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Mississippi Valley State | 5 | at | Southern Mississippi | 13 | FINAL | Box Score | Recap | |
| Summit League |
| 4/21/2009 |
| Northwestern State | 10 | at | Centenary | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Southern Utah | 7 | at | Utah Valley State | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Western Illinois | 7 | vs | Iowa | 20 | FINAL | Box Score | Recap | Davenport, IA |
| 4/21/2009 |
| #13 Arkansas | 9 | at | Oral Roberts | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Central Michigan |
| at | Oakland |
| Canceled | | Recap | CCD, rain |
| Sun Belt Conference |
| 4/21/2009 |
| South Alabama | 11 | at | Nicholls State | 2 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Tulane | 8 | at | New Orleans | 3 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| UAB | 3 | at | Troy | 11 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Arkansas-Little Rock | 1 | at | #11 Mississippi | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Arkansas State | 2 | at | Tennessee-Martin | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Florida Atlantic | 5 | at | Bethune-Cookman | 4 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Florida Memorial | 8 | at | Florida International | 19 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| McNeese State | 2 | at | Louisiana-Monroe | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Middle Tennessee State | 10 | at | Mississippi State | 6 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 4/21/2009 |
| Pepperdine | 8 | at | Cal State Northridge | 9 | FINAL | Box Score | Recap | 11 innings |
| 4/21/2009 |
| Portland | 5 | at | Washington | 6 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| San Jose State | 0 | at | San Francisco | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Southern California | 13 | at | Loyola Marymount | 5 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| St. Mary's | 7 | at | UC Davis | 8 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| #28 San Diego | 5 | at | #9 Cal State Fullerton | 8 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 4/21/2009 |
| Pacific | 10 | at | Nevada | 7 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| San Jose State | 0 | at | San Francisco | 10 | FINAL | Box Score | Recap | |
| 4/21/2009 |
| Texas Wesleyan | 9 | at | Louisiana Tech | 11 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2009 |
| Texas Wesleyan | 7 | at | Louisiana Tech | 16 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2009 |
| Hawaii | 2 | at | #3 Arizona State | 17 | FINAL | Box Score | Recap | |