| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/21/2012 | * | #26 Georgia | 5 | at | #1 Florida | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #11 Miami, Florida | 1 | at | #2 Florida State | 6 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #5 LSU | 1 | at | #3 Kentucky | 8 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #4 Texas A&M | 0 | at | #13 Baylor | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #6 South Carolina | 5 | at | Auburn | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Georgia Tech | 6 | at | #7 North Carolina | 12 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Georgia Tech | 4 | at | #7 North Carolina | 2 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | #19 Arizona State | 7 | at | #8 Stanford | 8 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #9 UCLA | 0 | at | #20 Oregon State | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #10 UCF | 8 | at | Tulane | 7 | FINAL | Box Score | Recap | 12 innings |
| 4/21/2012 | * | #29 East Carolina | 2 | at | #12 Rice | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/21/2012 | * | Washington State | 8 | at | #14 Oregon | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #15 Arkansas | 2 | at | #23 Mississippi | 8 | FINAL | Box Score | Recap | Resumption of 4/20 game |
| 4/21/2012 | * | #15 Arkansas | 0 | at | #23 Mississippi | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #16 Arizona | 4 | at | Washington | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #17 Purdue | 3 | at | Nebraska | 8 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Cal Poly | 8 | at | #18 Cal State Fullerton | 6 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | St. Mary's | 4 | at | #21 San Diego | 12 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #22 Louisville |
| at | South Florida |
| Suspended | | Recap | Suspended to 4/22, inclement weather (12-1 Louisville, b7) |
| 4/21/2012 | * | Boston College | 0 | at | #24 NC State | 9 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Boston College | 9 | at | #24 NC State | 16 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | Kansas | 0 | at | #25 Texas | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #27 Virginia | 12 | at | Duke | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #27 Virginia | 10 | at | Duke | 3 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | #28 Sam Houston State | 5 | at | McNeese State | 2 | FINAL | Box Score | Recap | makeup of 4/20 game |
| 4/21/2012 | * | #28 Sam Houston State | 4 | at | McNeese State | 0 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #30 Gonzaga | 1 | at | San Francisco | 2 | FINAL | Box Score | Recap | |
  |
| America East Conference |
| 4/21/2012 | * | Albany | 13 | at | UMBC | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Albany | 11 | at | UMBC | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Hartford | 0 | at | Stony Brook | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Hartford | 4 | at | Stony Brook | 9 | FINAL | Box Score | Recap | 600th career win for Stony Brook's Matt Senk |
| 4/21/2012 | * | Maine |
| at | Binghamton |
| Canceled | | Recap | CCD, rain (Ithaca, NY) |
| 4/21/2012 | * | Maine |
| at | Binghamton |
| Canceled | | Recap | CCD, rain (Ithaca, NY) |
| Atlantic 10 Conference |
| 4/21/2012 | * | LaSalle | 1 | at | Fordham | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | LaSalle | 2 | at | Fordham | 1 | FINAL | Box Score | Recap | 12 innings |
| 4/21/2012 | * | Massachusetts | 2 | at | St. Louis | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Richmond | 9 | at | Temple | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Richmond | 6 | at | Temple | 7 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | St. Bonaventure | 2 | at | George Washington | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | St. Bonaventure | 9 | at | George Washington | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | St. Joseph's | 2 | at | Charlotte | 7 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Xavier | 14 | at | Rhode Island | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Xavier | 5 | at | Rhode Island | 9 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Dayton | 4 | at | Evansville | 3 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/21/2012 | * | #11 Miami, Florida | 1 | at | #2 Florida State | 6 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Georgia Tech | 6 | at | #7 North Carolina | 12 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Georgia Tech | 4 | at | #7 North Carolina | 2 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | Boston College | 0 | at | #24 NC State | 9 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Boston College | 9 | at | #24 NC State | 16 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | #27 Virginia | 12 | at | Duke | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #27 Virginia | 10 | at | Duke | 3 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | Clemson | 5 | at | Maryland | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Clemson | 7 | at | Maryland | 2 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | Virginia Tech | 8 | at | Wake Forest | 6 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Virginia Tech | 6 | at | Wake Forest | 8 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| Atlantic Sun Conference |
| 4/21/2012 | * | Belmont | 11 | at | Kennesaw State | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Jacksonville | 2 | at | South Carolina-Upstate | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Lipscomb | 2 | at | Stetson | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Mercer | 8 | at | East Tennessee State | 13 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Florida Gulf Coast | 6 | at | New Mexico | 12 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 4/21/2012 | * | #17 Purdue | 3 | at | Nebraska | 8 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Minnesota | 2 | at | Michigan State | 3 | FINAL | Box Score | Recap | 11 innings (makeup of 4/20 game) |
| 4/21/2012 | * | Minnesota | 4 | at | Michigan State | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Northwestern | 6 | at | Michigan | 5 | FINAL | Box Score | Recap | 11 innings (makeup of 4/20 game) |
| 4/21/2012 | * | Northwestern | 8 | at | Michigan | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Ohio State | 3 | at | Illinois | 8 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Penn State | 2 | at | Iowa | 0 | FINAL | Box Score | Recap | No-hitter for Penn State's Steven Hill |
| 4/21/2012 |
| Georgia Southern | 0 | at | Indiana | 3 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 4/21/2012 | * | #4 Texas A&M | 0 | at | #13 Baylor | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Kansas | 0 | at | #25 Texas | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Kansas State | 3 | at | Missouri | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Texas Tech | 2 | at | Oklahoma State | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Alabama State | 1 | at | Oklahoma | 2 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/21/2012 | * | #22 Louisville |
| at | South Florida |
| Suspended | | Recap | Suspended to 4/22, inclement weather (12-1 Louisville, b7) |
| 4/21/2012 | * | Notre Dame | 14 | at | Georgetown | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Pittsburgh |
| at | West Virginia |
| Postponed | | Recap | PPD to 4/22, inclement weather |
| 4/21/2012 | * | Rutgers | 15 | at | Connecticut | 0 | FINAL | Box Score | Recap | Norwich, CT |
| 4/21/2012 | * | St. John's | 9 | at | Cincinnati | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Villanova | 7 | at | Seton Hall | 4 | FINAL | Box Score | Recap | 12 innings |
| 4/21/2012 | * | Villanova | 12 | at | Seton Hall | 5 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| Big South Conference |
| 4/21/2012 | * | Campbell | 7 | at | VMI | 8 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Charleston Southern | 7 | at | Presbyterian | 4 | FINAL | Box Score | Recap | 10 innings |
| 4/21/2012 | * | High Point | 7 | at | Coastal Carolina | 9 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | High Point | 7 | at | Coastal Carolina | 17 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | Liberty | 0 | at | UNC Asheville | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Radford | 9 | at | Winthrop | 0 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Gardner-Webb | 1 | at | UAB | 5 | FINAL | Box Score | Recap | |
| Big West Conference |
| 4/21/2012 | * | Cal Poly | 8 | at | #18 Cal State Fullerton | 6 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | UC Davis | 6 | at | UC Riverside | 7 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | UC Irvine | 3 | at | Long Beach State | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | UC Santa Barbara | 9 | at | Pacific | 2 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/21/2012 | * | Georgia State | 1 | at | Towson | 11 | FINAL | Box Score | Recap | Resumption of 4/20 game |
| 4/21/2012 | * | Georgia State | 14 | at | Towson | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | James Madison | 20 | at | Hofstra | 14 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | James Madison | 13 | at | Hofstra | 15 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | Old Dominion | 1 | at | George Mason | 7 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Old Dominion | 6 | at | George Mason | 16 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | UNC Wilmington | 7 | at | Northeastern | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | UNC Wilmington | 7 | at | Northeastern | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | William and Mary | 4 | at | VCU | 7 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | William and Mary | 4 | at | VCU | 5 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| Conference USA |
| 4/21/2012 | * | #10 UCF | 8 | at | Tulane | 7 | FINAL | Box Score | Recap | 12 innings |
| 4/21/2012 | * | #29 East Carolina | 2 | at | #12 Rice | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/21/2012 | * | Marshall | 4 | at | Houston | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Memphis | 0 | at | Southern Mississippi | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Gardner-Webb | 1 | at | UAB | 5 | FINAL | Box Score | Recap | |
| Division I Independents |
| 4/21/2012 |
| Cal State Bakersfield | 8 | at | Fresno State | 1 | FINAL | Box Score | Recap | makeup of 3/17 game |
| 4/21/2012 |
| Concordia (OR) | 4 | at | Seattle | 9 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Dallas Baptist | 3 | at | Indiana State | 6 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Nebraska-Omaha | 1 | at | Oakland | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Nebraska-Omaha | 3 | at | Oakland | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| North Carolina A&T | 3 | at | Longwood | 4 | FINAL | Box Score | Recap | 11 innings |
| 4/21/2012 |
| North Carolina A&T | 3 | at | Longwood | 4 | FINAL | Box Score | Recap | 7 innings |
| Great West Conference |
| 4/21/2012 | * | Chicago State | 20 | at | New York Tech | 9 | FINAL | Box Score | Recap | 8 innings |
| 4/21/2012 | * | Chicago State | 15 | at | New York Tech | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Houston Baptist | 3 | at | Northern Colorado | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Houston Baptist | 17 | at | Northern Colorado | 5 | FINAL | Box Score | Recap | 8 innings |
| 4/21/2012 | * | North Dakota | 7 | at | New Jersey Tech | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | North Dakota | 6 | at | New Jersey Tech | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | UT Pan American | 3 | at | Utah Valley | 13 | FINAL | Box Score | Recap | 8 innings, run rule |
| Horizon League |
| 4/21/2012 | * | Butler | 2 | at | Valparaiso | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Wright State | 2 | at | Illinois-Chicago | 0 | FINAL | Box Score | Recap | makeup of 4/20 game |
| 4/21/2012 | * | Wright State | 2 | at | Illinois-Chicago | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Youngstown State | 2 | at | Wisconsin-Milwaukee | 3 | FINAL | Box Score | Recap | makeup of 4/20 game |
| 4/21/2012 | * | Youngstown State | 1 | at | Wisconsin-Milwaukee | 8 | FINAL | Box Score | Recap | |
| Ivy League |
| 4/21/2012 | * | Brown | 5 | at | Harvard | 6 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Brown | 22 | at | Harvard | 9 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Cornell | 3 | at | Pennsylvania | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Cornell | 3 | at | Pennsylvania | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Princeton | 7 | at | Columbia | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Princeton | 5 | at | Columbia | 8 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Yale | 0 | at | Dartmouth | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Yale | 4 | at | Dartmouth | 8 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 4/21/2012 | * | Fairfield | 3 | at | Niagara | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Fairfield |
| at | Niagara |
| Postponed | | Recap | PPD to 4/22, inclement weather |
| 4/21/2012 | * | Manhattan | 3 | at | Canisius | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Manhattan |
| at | Canisius |
| Postponed | | Recap | PPD to 4/22, inclement weather |
| 4/21/2012 | * | Marist | 13 | at | Rider | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Marist | 4 | at | Rider | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | St. Peter's | 4 | at | Siena | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | St. Peter's | 4 | at | Siena | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Iona | 10 | at | Wagner | 18 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 4/21/2012 | * | Akron | 3 | at | Western Michigan | 1 | FINAL | Box Score | Recap | makeup of 4/20 game |
| 4/21/2012 | * | Akron | 6 | at | Western Michigan | 10 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Bowling Green State | 0 | at | Miami, Ohio | 7 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Buffalo | 3 | at | Ohio | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Eastern Michigan | 4 | at | Ball State | 0 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Kent State | 6 | at | Central Michigan | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Toledo | 5 | at | Northern Illinois | 1 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 4/21/2012 | * | Bethune-Cookman | 5 | at | North Carolina Central | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Bethune-Cookman | 3 | at | North Carolina Central | 4 | FINAL | Box Score | Recap | 8 innings |
| 4/21/2012 | * | Coppin State | 1 | at | Norfolk State | 9 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Coppin State | 6 | at | Norfolk State | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Florida A&M | 0 | at | Savannah State | 6 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Florida A&M | 8 | at | Savannah State | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | UMES | 2 | at | Delaware State | 17 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 |
| North Carolina A&T | 3 | at | Longwood | 4 | FINAL | Box Score | Recap | 11 innings |
| 4/21/2012 |
| North Carolina A&T | 3 | at | Longwood | 4 | FINAL | Box Score | Recap | 7 innings |
| Missouri Valley Conference |
| 4/21/2012 | * | Bradley | 3 | at | Illinois State | 12 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Creighton | 0 | at | Southern Illinois | 4 | FINAL | Box Score | Recap | makeup of 4/20 game |
| 4/21/2012 | * | Creighton | 6 | at | Southern Illinois | 7 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Missouri State | 7 | at | Wichita State | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Dallas Baptist | 3 | at | Indiana State | 6 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Dayton | 4 | at | Evansville | 3 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 4/21/2012 | * | Air Force | 6 | at | UNLV | 7 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | TCU | 5 | at | San Diego State | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Florida Gulf Coast | 6 | at | New Mexico | 12 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/21/2012 | * | Bryant | 5 | at | Quinnipiac | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Bryant | 22 | at | Quinnipiac | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Central Connecticut State | 3 | at | Fairleigh Dickinson | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Central Connecticut State | 12 | at | Fairleigh Dickinson | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Mount St. Mary's | 4 | at | Monmouth | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Mount St. Mary's | 1 | at | Monmouth | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Sacred Heart | 1 | at | Long Island | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Sacred Heart | 6 | at | Long Island | 3 | FINAL | Box Score | Recap | 11 innings |
| 4/21/2012 |
| Iona | 10 | at | Wagner | 18 | FINAL | Box Score | Recap | |
| Ohio Valley Conference |
| 4/21/2012 | * | Austin Peay State | 6 | at | Eastern Kentucky | 7 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Morehead State | 6 | at | Eastern Illinois | 3 | FINAL | Box Score | Recap | makeup of 4/20 game |
| 4/21/2012 | * | Morehead State | 13 | at | Eastern Illinois | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Murray State | 1 | at | Jacksonville State | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Tennessee Tech | 8 | at | Southeast Missouri State | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Tennessee-Martin | 2 | at | Southern Illinois-Edwardsville | 10 | FINAL | Box Score | Recap | |
| Pac 12 Conference |
| 4/21/2012 | * | #19 Arizona State | 7 | at | #8 Stanford | 8 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #9 UCLA | 0 | at | #20 Oregon State | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Washington State | 8 | at | #14 Oregon | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #16 Arizona | 4 | at | Washington | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Utah | 0 | at | California | 9 | FINAL | Box Score | Recap | |
| Patriot League |
| 4/21/2012 | * | Bucknell | 0 | at | Army | 8 | FINAL | Box Score | Recap | No-hitter for Army's Logan Lee (7 innings) |
| 4/21/2012 | * | Bucknell | 1 | at | Army | 2 | FINAL | Box Score | Recap | 15 innings |
| 4/21/2012 | * | Holy Cross | 3 | at | Lehigh | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Holy Cross | 16 | at | Lehigh | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Navy | 13 | at | Lafayette | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Navy | 21 | at | Lafayette | 3 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 4/21/2012 | * | #26 Georgia | 5 | at | #1 Florida | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #5 LSU | 1 | at | #3 Kentucky | 8 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #6 South Carolina | 5 | at | Auburn | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #15 Arkansas | 2 | at | #23 Mississippi | 8 | FINAL | Box Score | Recap | Resumption of 4/20 game |
| 4/21/2012 | * | #15 Arkansas | 0 | at | #23 Mississippi | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Tennessee | 2 | at | Mississippi State | 3 | FINAL | Box Score | Recap | 14 innings |
| 4/21/2012 | * | Vanderbilt | 6 | at | Alabama | 8 | FINAL | Box Score | Recap | |
| Southern Conference |
| 4/21/2012 | * | Davidson | 2 | at | UNC Greensboro | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Davidson | 6 | at | UNC Greensboro | 8 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | Elon | 13 | at | Wofford | 3 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Elon | 0 | at | Wofford | 2 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | Furman | 5 | at | Appalachian State | 6 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Furman | 0 | at | Appalachian State | 14 | FINAL | Box Score | Recap | moved from 4/22, impending weather |
| 4/21/2012 | * | The Citadel | 2 | at | College of Charleston | 7 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Western Carolina | 2 | at | Samford | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Georgia Southern | 0 | at | Indiana | 3 | FINAL | Box Score | Recap | |
| Southland Conference |
| 4/21/2012 | * | #28 Sam Houston State | 5 | at | McNeese State | 2 | FINAL | Box Score | Recap | makeup of 4/20 game |
| 4/21/2012 | * | #28 Sam Houston State | 4 | at | McNeese State | 0 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Central Arkansas | 1 | at | Texas State | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Lamar | 4 | at | Nicholls State | 10 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Northwestern State | 4 | at | UT Arlington | 13 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Southeastern Louisiana | 3 | at | UTSA | 9 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Stephen F. Austin | 4 | at | Texas A&M-Corpus Christi | 2 | FINAL | Box Score | Recap | makeup of 4/20 game |
| 4/21/2012 | * | Stephen F. Austin | 2 | at | Texas A&M-Corpus Christi | 1 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 4/21/2012 | * | Alabama A&M | 0 | at | Mississippi Valley State | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Alabama A&M | 3 | at | Mississippi Valley State | 4 | FINAL | Box Score | Recap | 12 innings |
| 4/21/2012 | * | Arkansas-Pine Bluff | 4 | at | Texas Southern | 5 | FINAL | Box Score | Recap | 10 innings |
| 4/21/2012 | * | Arkansas-Pine Bluff | 4 | at | Texas Southern | 6 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Jackson State | 6 | at | Alcorn State | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Jackson State | 4 | at | Alcorn State | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Southern | 8 | at | Prairie View A&M | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Southern | 3 | at | Prairie View A&M | 0 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Alabama State | 1 | at | Oklahoma | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Wiley | 1 | at | Grambling State | 11 | FINAL | Box Score | | 7 innings |
| 4/21/2012 |
| Wiley | 0 | at | Grambling State | 2 | FINAL | Box Score | | 7 innings |
| Summit League |
| 4/21/2012 | * | IUPU-Fort Wayne | 2 | at | Southern Utah | 8 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | South Dakota State | 6 | at | North Dakota State | 7 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | South Dakota State | 2 | at | North Dakota State | 3 | FINAL | Box Score | Recap | 8 innings |
| 4/21/2012 | * | Western Illinois | 0 | at | Oral Roberts | 10 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 | * | Western Illinois | 0 | at | Oral Roberts | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/21/2012 |
| Nebraska-Omaha | 1 | at | Oakland | 4 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Nebraska-Omaha | 3 | at | Oakland | 4 | FINAL | Box Score | Recap | |
| Sun Belt Conference |
| 4/21/2012 | * | Arkansas State |
| at | Florida Atlantic |
| Canceled | | Recap | CCD, field conditions (makeup of 4/20 game) |
| 4/21/2012 | * | Arkansas State |
| at | Florida Atlantic |
| Postponed | | Recap | PPD to 4/21, field conditions |
| 4/21/2012 | * | Arkansas-Little Rock |
| at | Florida International |
| Suspended | | Recap | Suspended to 4/22, inclement weather (5-2 FIU, t4) |
| 4/21/2012 | * | Louisiana-Lafayette | 6 | at | South Alabama | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Middle Tennessee State | 0 | at | Louisiana-Monroe | 13 | FINAL | Box Score | Recap | makeup of 4/20 game |
| 4/21/2012 | * | Middle Tennessee State | 3 | at | Louisiana-Monroe | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Troy | 4 | at | Western Kentucky | 9 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 4/21/2012 | * | St. Mary's | 4 | at | #21 San Diego | 12 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | #30 Gonzaga | 1 | at | San Francisco | 2 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Pepperdine | 6 | at | Santa Clara | 5 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Portland | 6 | at | Loyola Marymount | 3 | FINAL | Box Score | Recap | 300th career win for Portland's Chris Sperry |
| Western Athletic Conference |
| 4/21/2012 | * | Hawaii | 4 | at | San Jose State | 1 | FINAL | Box Score | Recap | |
| 4/21/2012 | * | Louisiana Tech | 0 | at | New Mexico State | 10 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/21/2012 | * | Nevada | 7 | at | Sacramento State | 8 | FINAL | Box Score | Recap | |
| 4/21/2012 |
| Cal State Bakersfield | 8 | at | Fresno State | 1 | FINAL | Box Score | Recap | makeup of 3/17 game |